Ferencz Ágnes, Orvos Hajnalka, Hermesz Edit
Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, P.O. Box 533, H-6701 Szeged, Hungary.
Department of Obstetrics and Gynaecology, University of Szeged, P.O. Box 533, H-6701 Szeged, Hungary.
Reprod Toxicol. 2015 Jun;53:10-4. doi: 10.1016/j.reprotox.2015.02.008. Epub 2015 Feb 24.
Intrauterine growth restriction (IUGR) is a pleiotropic complication of pregnancy. Prematurity and growth abnormalities are common risk factors for perinatal morbidity and mortality. Free radical damage has been recognized as a common pathogenic mechanism of many neonatal diseases. The aim of the present study was to characterize the possible links between the level of maturity, the birthweight and the antioxidant status of neonates born with IUGR. Our data suggest that the stress markers measured on the cord blood of neonates with IUGR and mature, healthy neonates do not necessarily reflect the extent of oxidative stress. However, significant correlations were found between the maturity of the neonates with IUGR and the oxidative damage. The mature IUGRs exhibited ONOO(-) accumulation and increased lipid peroxidation more frequently as compared with the pre-term group. The results suggest that the oxidative injury in IUGR may depend on the level of maturity and the birthweight.
宫内生长受限（IUGR）是一种妊娠的多效性并发症。早产和生长异常是围产期发病和死亡的常见危险因素。自由基损伤已被认为是许多新生儿疾病的常见致病机制。本研究的目的是确定宫内生长受限新生儿的成熟度水平、出生体重与抗氧化状态之间的可能联系。我们的数据表明，在宫内生长受限新生儿和成熟、健康新生儿的脐带血中检测到的应激标志物不一定反映氧化应激的程度。然而，在宫内生长受限新生儿的成熟度与氧化损伤之间发现了显著相关性。与早产组相比，足月宫内生长受限新生儿更频繁地出现过氧亚硝酸盐（ONOO(-)）积累和脂质过氧化增加。结果表明，宫内生长受限中的氧化损伤可能取决于成熟度水平和出生体重。
