日本结节病患者中Toll样受体3单核苷酸多态性

A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis.

作者信息

Ikezoe K, Handa T, Tanizawa K, Kubo T, Ito I, Sokai A, Nakatsuka Y, Nagai S, Izumi T, Mishima M

机构信息

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

出版信息

Tissue Antigens. 2015 Mar;85(3):204-8. doi: 10.1111/tan.12535.

DOI:10.1111/tan.12535

PMID:25720507

Abstract

Toll-like receptor 3 (TLR3) may be associated with T helper 1 immune response. This study aimed to investigate the role of a functional TLR3 single nucleotide polymorphism (SNP) in sarcoidosis. We genotyped 220 Japanese patients with sarcoidosis and 140 controls for TLR3 SNP rs3775291 to analyze its association with susceptibility to sarcoidosis and assessed its relationship to clinical features in 172 patients over 2 years. The TLR3 rs3775291 genotype was not significantly associated with disease susceptibility. However, patients with cardiac sarcoidosis (CS) significantly more frequently had the TT genotype (p < 0.01) or the T allele (p < 0.05) than those patients without CS. We conclude that TLR3 SNP rs3775291 may affect cardiac involvement in Japanese patients with sarcoidosis.

摘要

Toll样受体3（TLR3）可能与辅助性T细胞1免疫反应相关。本研究旨在探讨功能性TLR3单核苷酸多态性（SNP）在结节病中的作用。我们对220例日本结节病患者和140例对照进行了TLR3 SNP rs3775291基因分型，以分析其与结节病易感性的关联，并在2年时间里评估了其与172例患者临床特征的关系。TLR3 rs3775291基因型与疾病易感性无显著关联。然而，心脏结节病（CS）患者的TT基因型（p < 0.01）或T等位基因（p < 0.05）出现频率显著高于无CS的患者。我们得出结论，TLR3 SNP rs3775291可能影响日本结节病患者的心脏受累情况。