Graduate Program in Epidemiology and Health Surveillance (PPGEVS), Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
Postgraduate Program in Parasitic Biology in the Amazon (PPGBPA), University of State of Pará (UEPA), Belém 66087-670, PA, Brazil.
Genes (Basel). 2023 Jun 21;14(7):1311. doi: 10.3390/genes14071311.
As the host's first line of defense against pathogens, (), such as the , are genes encoding transmembrane receptors of the same name. Depending on their expression, TLRs cause a pro- or anti-inflammatory response. The purpose of the article was to determine whether there is an association between the () rs3775291 Single Nucleotide Polymorphism-SNP and susceptibility to infections. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and was registered in PROSPERO under the code CRD42023429533. A systematic search for relevant studies was performed using PubMed, Scopus, SciELO, Google Scholar, and Science Direct by the MeSH descriptors and the Boolean Operator "AND": "Infections"; "TLR3"; "SNP", between January 2005 and July 2022. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated for genotypic comparison assuming a dominant genetic model (CT + TT vs. CC). A meta-analysis of 18 studies consisting of 3118 cases and 4368 controls found a significant association for risk between the presence of the SNP rs3775291 and infections as part of the general analysis (OR = 1.16, 95% CI = 1.04-1.28, = 0.004). In the subgroups of continents, the SNP had a protective role in Europe for 1044 cases and 1471 controls (OR = 0.83, 95% CI = 0.70-0.99, = 0.04); however, the Asian (for 1588 patients and 2306 controls) and American (for 486 patients and 591 controls) continents had an increase in infectious risk (OR = 1.37, 95% CI = 1.19-1.58, < 0.001; OR = 1.42, 95% CI = 1.08-1.86, and = 0.01, respectively). Heterogeneity between studies was detected (I = 58%) but was explained in meta-regression by the subgroup of continents itself and publication bias was not evident. The results of the meta-analysis suggest a significant association between the rs3775291 polymorphism and susceptibility to infections. Thus, when analyzing subgroups, the Asian and American continents showed that this SNP confers a higher risk against infections in a dominant genotypic model. Therefore, more studies are necessary to fully elucidate the role of rs3775291 in infections.
作为宿主抵御病原体的第一道防线，（），例如 ，是编码同名跨膜受体的基因。根据其表达情况，TLR 会引起促炎或抗炎反应。本文旨在确定 （）rs3775291 单核苷酸多态性-SNP 与感染易感性之间是否存在关联。本综述根据系统评价和荟萃分析的首选报告项目（PRISMA）2020 指南进行，并在 PROSPERO 中以 CRD42023429533 代码进行了注册。使用 PubMed、Scopus、SciELO、Google Scholar 和 Science Direct 通过 MeSH 描述符和布尔运算符“AND”对相关研究进行了系统搜索：“感染”；“TLR3”；“SNP”，时间范围为 2005 年 1 月至 2022 年 7 月。假设显性遗传模型（CT + TT vs. CC），计算基因型比较的汇总优势比（OR）和相应的 95%置信区间（CI）。对包括 3118 例病例和 4368 例对照的 18 项研究进行的荟萃分析发现，在一般分析中， SNP rs3775291 与感染之间存在显著的风险关联（OR = 1.16，95%CI = 1.04-1.28， = 0.004）。在各大陆的亚组中， SNP 对欧洲的 1044 例病例和 1471 例对照具有保护作用（OR = 0.83，95%CI = 0.70-0.99， = 0.04）；然而，亚洲（1588 例患者和 2306 例对照）和美洲（486 例患者和 591 例对照）大陆的感染风险增加（OR = 1.37，95%CI = 1.19-1.58， < 0.001；OR = 1.42，95%CI = 1.08-1.86， = 0.01）。检测到研究之间存在异质性（I = 58%），但在亚组荟萃回归中通过大陆亚组本身进行了解释，且不存在发表偏倚。荟萃分析结果表明， （）rs3775291 多态性与感染易感性之间存在显著关联。因此，在分析亚组时，亚洲和美洲大陆表明，这种 SNP 在显性基因型模型中赋予了更高的感染风险。因此，需要更多的研究来充分阐明 （）rs3775291 在感染中的作用。
