用于阿霉素和伊立替康高效联合治疗的脂质-聚合物纳米结构平台的工程设计
Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan.
作者信息
Ramasamy T, Ruttala H B, Choi J Y, Tran T H, Kim J H, Ku S K, Choi H G, Yong C S, Kim J O
机构信息
College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, 712-749, South Korea.
出版信息
Chem Commun (Camb). 2015 Apr 4;51(26):5758-61. doi: 10.1039/c5cc00482a.
PMID:25720556
Abstract
We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer. It shows great potential for the treatment of a broad range of cancers.
摘要
我们开发了一种高度稳定的脂质-聚合物纳米结构平台，用于在聚电解质复合纳米颗粒核心中对阿霉素和伊立替康进行有效的联合治疗，随后将整个组件整合到卵磷脂双分子层中。它在治疗多种癌症方面显示出巨大潜力。
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