Kensese S M, Smith L L
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550.
Teratog Carcinog Mutagen. 1989;9(4):211-8. doi: 10.1002/tcm.1770090404.
In bioassays conducted under controlled, comparable conditions, weak direct mutagenicity responses were observed for hydrogen peroxide in the standard (Ames test) agar plate incorporation bioassay with Salmonella typhimurium strains TA97, TA98, TA102, and TA1537, in a 20 min preincubation test with strains TA97, TA98, TA100, TA102, TA1537, and TA1538, and in a liquid incubation modification using strain TA1537. These results conclusively demonstrate that hydrogen peroxide is a weak mutagen, especially in strains that are sensitive to oxidative damage under suitable bioassay conditions.
在可控的、可比条件下进行的生物测定中，在标准（艾姆斯试验）琼脂平板掺入生物测定中，用鼠伤寒沙门氏菌菌株TA97、TA98、TA102和TA1537检测过氧化氢时观察到微弱的直接诱变反应；在与菌株TA97、TA98、TA100、TA102、TA1537和TA1538进行的20分钟预孵育试验中，以及在使用菌株TA1537的液体孵育改良试验中也观察到了这种反应。这些结果确凿地证明，过氧化氢是一种弱诱变剂，尤其是在合适的生物测定条件下对氧化损伤敏感的菌株中。
