Garcia Lucas da Fonseca Roberti, Huck Claudia, Scardueli Cassio Rocha, de Souza Costa Carlos Alberto
Department of Physiology and Pathology, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil.
Department of Diagnosis and Surgery, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil.
J Endod. 2015 Jun;41(6):864-70. doi: 10.1016/j.joen.2014.12.029. Epub 2015 Feb 24.
The aim of this study was to evaluate and compare the repair of bone defects filled with calcium aluminate cement (EndoBinder), mineral trioxide aggregate (MTA), and calcium hydroxide.
After mixing, the cements were inserted into bone defects (3.3 mm) mechanically created in the right and left tibias of 30 rats (Rattus norvegicus, Wistar). In the control group, the bone defects were filled with blood clot of the animal itself. After time intervals of 7, 30, and 90 days had elapsed, bone tissue biopsies (n = 5) were surgically obtained and submitted to laboratory processing. The response of bone tissue in contact with the materials was microscopically analyzed. The percentage of neoformed bone tissue in the defect was determined by means of planimetry counting points superimposed on the histologic image.
Significant increase in the percentage of neoformed bone tissue was observed throughout the experimental periods in all groups (P < .05). For the cements EndoBinder and MTA (30 and 90 days), these percentage values were statistically higher than those of the control group (P < .05); however, they were similar to those of calcium hydroxide (P > .05).
EndoBinder and MTA allowed complete repair of bone defects created in rat tibias.
本研究的目的是评估和比较用铝酸钙水泥（EndoBinder）、三氧化矿物凝聚体（MTA）和氢氧化钙填充的骨缺损修复情况。
将水泥混合后，机械性地植入30只大鼠（褐家鼠，Wistar）左右胫骨中人为制造的骨缺损（3.3毫米）内。对照组的骨缺损用动物自身的血凝块填充。在7天、30天和90天的时间间隔后，通过手术获取骨组织活检样本（n = 5）并进行实验室处理。对与材料接触的骨组织反应进行显微镜分析。通过在组织学图像上叠加的面积测量计数点来确定缺损处新形成骨组织的百分比。
在整个实验期间，所有组新形成骨组织的百分比均显著增加（P < 0.05）。对于EndoBinder和MTA水泥（30天和90天），这些百分比值在统计学上高于对照组（P < 0.05）；然而，它们与氢氧化钙组相似（P > 0.05）。
EndoBinder和MTA能够使大鼠胫骨中制造的骨缺损完全修复。
