Paz Jessica Emanuella Rocha, Costa Priscila Oliveira, Souza Albert Alexandre Costa, de Oliveira Ingrid Macedo, Falcão Lucas Fernandes, Falcão Carlos Alberto Monteiro, Ferraz Maria Ângela Area Leão, Pinto Lucielma Salmito Soares
Department of Oral & Maxillofacial Surgery and Periodontology, São Paulo University, School of Dentistry, Ribeirão Preto, SP, Brazil.
Department of Endodontics, Dental School, Uninovafapi University Center, Teresina, PI, Brazil.
Restor Dent Endod. 2021 Sep 2;46(4):e48. doi: 10.5395/rde.2021.46.e48. eCollection 2021 Nov.
This study aimed to evaluate the effects on bone repair of different concentrations of mineral trioxide aggregate (MTA) added to AH Plus.
Bone tissue reactions were evaluated in 30 rats () after 7 and 30 days. In the AH + MTA10, AH + MTA20, and AH + MTA30 groups, defects in the tibiae were filled with AH Plus with MTA in proportions of 10%, 20% and 30%, respectively; in the MTA-FILL group, MTA Fillapex was used; and in the control group, no sealer was used. The samples were histologically analyzed to assess bone union and maturation. The Kruskal-Wallis and Mann-Whitney tests were performed for multiple pairwise comparisons ( ≤ 0.05).
At the 7-day time point, AH + MTA10 was superior to MTA-FILL with respect to bone union, and AH + MTA20 was superior to MTA-FILL with respect to bone maturity ( < 0.05). At the 30-day time point, both the AH + MTA10 and AH + MTA20 experimental sealers were superior not only to MTA-FILL, but also to AH + MTA30 with respect to both parameters ( < 0.05). The results of the AH + MTA10 and AH + MTA20 groups were superior to those of the control group for both parameters and experimental time points ( < 0.05).
The results suggest the potential benefit of using a combination of these materials in situations requiring bone repair.
本研究旨在评估添加到AH Plus中的不同浓度的三氧化矿物凝聚体（MTA）对骨修复的影响。
在30只大鼠中于7天和30天后评估骨组织反应。在AH + MTA10组、AH + MTA20组和AH + MTA30组中，分别用含10%、20%和30% MTA的AH Plus填充胫骨缺损；在MTA - FILL组中，使用MTA Fillapex；在对照组中，不使用封闭剂。对样本进行组织学分析以评估骨愈合和成熟情况。进行Kruskal - Wallis和Mann - Whitney检验用于多重两两比较（P≤0.05）。
在7天时间点，就骨愈合而言，AH + MTA10优于MTA - FILL，就骨成熟而言，AH + MTA20优于MTA - FILL（P<0.05）。在30天时间点，AH + MTA10和AH + MTA20这两种实验性封闭剂在这两个参数方面不仅优于MTA - FILL，而且优于AH + MTA30（P<0.05）。在两个参数和实验时间点上，AH + MTA10组和AH + MTA20组的结果均优于对照组（P<0.05）。
结果表明在需要骨修复的情况下使用这些材料组合具有潜在益处。
