Medlow Paul, McEneny Jane, Murphy Marie H, Trinick Tom, Duly Ellie, Davison Gareth W
Sport and Exercise Science Research Institute, Ulster University, Jordanstown, Co. Antrim, Northern Ireland, BT37 OQB, UK.
Centre for Public Health, School of Medicine, Queens University Belfast, BT12 6BJ, UK.
Atherosclerosis. 2015 Apr;239(2):516-22. doi: 10.1016/j.atherosclerosis.2015.02.012. Epub 2015 Feb 7.
Exercise training is considered an effective strategy to improve metabolic disease. Despite this, less is known regarding exercise training in the prevention and susceptibility of LDL subfraction oxidation, particularly in an aged population.
Eleven aged (55 ± 4 yrs) and twelve young (21 ± 2 yrs) participants were randomly separated into an experimental or control group as follows: young exercise (n = 6); young control (n = 6); aged exercise (n = 6) and aged control (n = 5). The participants assigned to the exercise groups performed 12 weeks of moderate intensity (55-65% VO2max) exercise training. Venous blood was extracted at baseline, and 48 h following 12 weeks of exercise and assayed for a range of metabolites associated with lipid composition and lipoprotein susceptibility to oxidation.
Although there was no difference in the oxidation potential (time ½ max) of LDL I, II or III between groups at baseline (p > 0.05), there was an increase in time ½ max for LDL I following exercise within the aged exercise group (p < 0.05). Moreover, α-tocopherol concentration was selectively lower in the aged exercise group, compared to the young exercise at baseline. The lipid composition of LDL I, LDL II, LDL III, VLDL, HDL2, HDL3 and serum lipid hydroperoxides remained unchanged as a function of exercise training and ageing (p > 0.05).
The primary finding of this study demonstrates that adaptations in LDL resistance to oxidation occur following 12 weeks of exercise training in the aged, and this may be of clinical significance, as oxidation of LDL has been implicated in atherosclerosis.
运动训练被认为是改善代谢性疾病的有效策略。尽管如此，关于运动训练在低密度脂蛋白（LDL）亚组分氧化的预防和易感性方面的研究较少，尤其是在老年人群中。
将11名老年人（55±4岁）和12名年轻人（21±2岁）随机分为实验组或对照组，如下：年轻运动组（n = 6）；年轻对照组（n = 6）；老年运动组（n = 6）和老年对照组（n = 5）。分配到运动组的参与者进行了12周的中等强度（55 - 65%最大摄氧量）运动训练。在基线时抽取静脉血，并在运动12周后的48小时抽取静脉血，检测一系列与脂质组成和脂蛋白氧化易感性相关的代谢物。
尽管在基线时各组之间LDL I、II或III的氧化电位（半数最大时间）没有差异（p > 0.05），但老年运动组运动后LDL I的半数最大时间增加（p < 0.05）。此外，与年轻运动组相比，老年运动组在基线时α - 生育酚浓度选择性降低。LDL I、LDL II、LDL III、极低密度脂蛋白（VLDL）、高密度脂蛋白2（HDL2）、高密度脂蛋白3（HDL3）的脂质组成以及血清脂质氢过氧化物在运动训练和衰老过程中保持不变（p > 0.05）。
本研究的主要发现表明，老年人群经过12周运动训练后，LDL抗氧化能力发生了适应性变化，这可能具有临床意义，因为LDL氧化与动脉粥样硬化有关。
