Georgia Prevention Institute, Department of Population Health Sciences, Augusta University, Augusta, GA, USA.
Medical Scientist Training Program, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Oxid Med Cell Longev. 2019 Jun 19;2019:1629638. doi: 10.1155/2019/1629638. eCollection 2019.
Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF). Oxidative stress may contribute to vascular dysfunction via inhibition of nitric oxide (NO) bioavailability. . To determine if ingestion of a single antioxidant cocktail (AOC) improves vascular endothelial function in patients with CF. . In 18 patients with CF (age 8-39 y), brachial artery flow-mediated dilation (FMD) was assessed using a Doppler ultrasound prior to and two hours following either an AOC ( = 18; 1,000 mg vitamin C, 600 IU vitamin E, and 600 mg -lipoic acid) or a placebo ( = 9). In a subgroup of patients ( = 9), changes in serum concentrations of -tocopherol and lipid hydroperoxide (LOOH) were assessed following AOC and placebo. . A significant ( = 0.032) increase in FMD was observed following AOC (Δ1.9 ± 3.3%), compared to no change following placebo (Δ - 0.8 ± 1.9%). Moreover, compared with placebo, AOC prevented the decrease in -tocopherol (Δ0.48 ± 2.91 vs. -1.98 ± 2.32 M, = 0.024) and tended to decrease LOOH (Δ - 0.2 ± 0.1 vs. 0.1 ± 0.1 M, = 0.063). . These data demonstrate that ingestion of an antioxidant cocktail can improve vascular endothelial function and improve oxidative stress in patients with CF, providing evidence that oxidative stress is a key contributor to vascular endothelial dysfunction in CF.
氧化应激和血管内皮功能障碍是囊性纤维化 (CF) 的既定特征。氧化应激可通过抑制一氧化氮 (NO) 的生物利用度来导致血管功能障碍。目的：确定单次摄入抗氧化鸡尾酒 (AOC) 是否能改善 CF 患者的血管内皮功能。方法：在 18 例 CF 患者（年龄 8-39 岁）中，使用多普勒超声在摄入 AOC（= 18；1000mg 维生素 C、600IU 维生素 E 和 600mg - 硫辛酸）或安慰剂（= 9）之前和之后两小时评估肱动脉血流介导的扩张 (FMD)。在患者的亚组（= 9）中，评估了 AOC 和安慰剂后血清 - 生育酚和脂质氢过氧化物 (LOOH) 浓度的变化。结果：与安慰剂相比，AOC 后 FMD 显著增加（= 0.032；Δ1.9 ± 3.3%），而安慰剂后无变化（Δ - 0.8 ± 1.9%）。此外，与安慰剂相比，AOC 可防止 - 生育酚下降（Δ0.48 ± 2.91 与 -1.98 ± 2.32 M，= 0.024），并倾向于降低 LOOH（Δ - 0.2 ± 0.1 与 0.1 ± 0.1 M，= 0.063）。结论：摄入抗氧化鸡尾酒可改善 CF 患者的血管内皮功能并改善氧化应激，这提供了证据表明氧化应激是 CF 中血管内皮功能障碍的关键因素。
