Wu Ling-Ling, Pang Rui-Ping, Yin Yu-Zhu, Shen Kai-Feng, Zhang Pei-Zhen
Department of Obstetrics and Gynecology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Gynecol Obstet Invest. 2015;79(3):189-94. doi: 10.1159/000367655. Epub 2015 Feb 14.
To investigate whether and how human chorionic gonadotropin (HCG) treatment ameliorates endometriosis in an endometriotic rat model.
Twenty-four endometriosis rats were established and were randomly divided into four groups, and then the rats were treated with 19.4, 25.8, and 51.6 IU/100 g weight/day of HCG, respectively. The control group was treated with 0.9% NaCl. After 15 days (3 estrous cycles), the ectopic lesion volume and the expression of leptin protein in eutopic and ectopic endometrium were investigated.
After HCG treatment, the volumes of endometriotic lesions were significantly smaller than those before treatment. During endometriosis development, the expression of leptin protein in eutopic and ectopic endometrium was remarkably increased. HCG administration reversed leptin upregulation in endometriotic tissues.
HCG therapy appears to be an effective treatment for endometriosis in rats through down-regulation of leptin expression in eutopic and ectopic endometrium.
研究人绒毛膜促性腺激素（HCG）治疗是否以及如何改善子宫内膜异位症大鼠模型中的子宫内膜异位症。
建立24只子宫内膜异位症大鼠模型，并随机分为四组，然后分别用19.4、25.8和51.6 IU/100 g体重/天的HCG对大鼠进行治疗。对照组用0.9%氯化钠治疗。15天后（3个发情周期），研究异位病变体积以及在位和异位子宫内膜中瘦素蛋白的表达。
HCG治疗后，子宫内膜异位症病变体积明显小于治疗前。在子宫内膜异位症发展过程中，在位和异位子宫内膜中瘦素蛋白的表达显著增加。给予HCG可逆转子宫内膜异位症组织中瘦素的上调。
HCG治疗似乎是通过下调在位和异位子宫内膜中瘦素的表达来有效治疗大鼠子宫内膜异位症。
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