Judd Michael C, Emukule Gideon O, Njuguna Henry, McMorrow Meredith L, Arunga Geoffrey O, Katz Mark A, Montgomery Joel M, Wong Joshua M, Breiman Robert F, Mott Joshua A
Department of Epidemiology, Rollins School of Public Health, Emory University.
International Emerging Infections Program, Centers for Disease Control and Prevention.
J Infect Dis. 2015 Sep 1;212(5):740-4. doi: 10.1093/infdis/jiv106. Epub 2015 Feb 25.
Little is known about how human immunodeficiency virus (HIV) infection affects influenza transmission within homes in sub-Saharan Africa.
We used respiratory illness surveillance and HIV testing data gathered in Kibera, an urban slum in Nairobi, Kenya, to examine the impact of HIV status on (1) introducing influenza to the home and (2) transmitting influenza to household contacts.
While HIV status did not affect the likelihood of being an influenza index case, household contacts of HIV-infected influenza index cases had twice the risk of developing secondary influenza-like illness than contacts of HIV-negative index cases.
HIV-infected influenza index cases may facilitate transmission of influenza within the home.
关于人类免疫缺陷病毒（HIV）感染如何影响撒哈拉以南非洲家庭内流感传播的情况，人们了解甚少。
我们利用在肯尼亚内罗毕一个城市贫民窟基贝拉收集的呼吸道疾病监测和HIV检测数据，来研究HIV状态对（1）将流感引入家庭以及（2）将流感传播给家庭接触者的影响。
虽然HIV状态不影响成为流感指示病例的可能性，但HIV感染的流感指示病例的家庭接触者发生继发性流感样疾病的风险是HIV阴性指示病例接触者的两倍。
HIV感染的流感指示病例可能会促进家庭内流感的传播。
