2013-2014 年和 2014-2015 年季节期间，前瞻性队列中 A 型和 B 型流感在家中的传播。

Household transmission of influenza A and B within a prospective cohort during the 2013-2014 and 2014-2015 seasons.

机构信息

Influenza Division, Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Battelle Memorial Institute, Atlanta, Georgia, USA.

出版信息

Stat Med. 2021 Dec 10;40(28):6260-6276. doi: 10.1002/sim.9181. Epub 2021 Sep 27.

DOI:10.1002/sim.9181

PMID:34580901

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9293304/

Abstract

People living within the same household as someone ill with influenza are at increased risk of infection. Here, we use Markov chain Monte Carlo methods to partition the hazard of influenza illness within a cohort into the hazard from the community and the hazard from the household. During the 2013-2014 influenza season, 49 (4.7%) of the 1044 people enrolled in a community surveillance cohort had an acute respiratory illness (ARI) attributable to influenza. During the 2014-2015 influenza season, 50 (4.7%) of the 1063 people in the cohort had an ARI attributable to influenza. The secondary attack rate from a household member was 2.3% for influenza A (H1) during 2013-2014, 5.3% for influenza B during 2013-2014, and 7.6% for influenza A (H3) during 2014-2015. Living in a household with a person ill with influenza increased the risk of an ARI attributable to influenza up to 350%, depending on the season and the influenza virus circulating within the household.

摘要

与流感患者同住一屋的人感染流感的风险增加。在这里，我们使用马尔可夫链蒙特卡罗方法将队列中流感疾病的危险划分为社区危险和家庭危险。在 2013-2014 流感季节，在一个社区监测队列中登记的 1044 人中，有 49 人（4.7%）因急性呼吸道疾病（ARI）而与流感有关。在 2014-2015 流感季节，队列中的 1063 人中有 50 人（4.7%）因 ARI 而与流感有关。在 2013-2014 年期间，从家庭成员感染甲型流感（H1）的二级攻击率为 2.3%，感染乙型流感的二级攻击率为 5.3%，感染甲型流感（H3）的二级攻击率为 7.6%。在 2014-2015 年期间，在一个家庭中与流感患者同住会使流感引起的 ARI 风险增加高达 350%，具体取决于季节和家庭中流行的流感病毒。