Turner D R, Kao Y J, Bivona C
Texas Tech University Health Sciences Center, Department of Anesthesiology, Lubbock 79430.
Br J Anaesth. 1989 Sep;63(3):348-50. doi: 10.1093/bja/63.3.348.
We have examined the effect of preoperative i.v. administration of three different histamine type 2 (H2) antagonists (cimetidine 400 mg, ranitidine 80 mg and famotidine 20 mg) or metoclopramide 10 mg i.v. on the duration of neuromuscular block produced by an intubating dose (1 mg kg-1) of suxamethonium. The study was conducted blindly in 70 post partum patients, weighing between 45 and 120 kg, scheduled for tubal ligation. The duration of neuromuscular block following suxamethonium was measured from a chart recording of train-of-four (TOF) electromyographic responses. The time from onset of 95% block to 25% recovery ("block time") was not significantly different between the groups receiving cimetidine (A), ranitidine (B), famotidine (C), and control (E). However, there was prolongation of neuromuscular block in patients receiving suxamethonium and metoclopramide (D).
我们研究了术前静脉注射三种不同的组胺2型（H2）拮抗剂（西咪替丁400毫克、雷尼替丁80毫克和法莫替丁20毫克）或静脉注射甲氧氯普胺10毫克对插管剂量（1毫克/千克）琥珀胆碱产生的神经肌肉阻滞持续时间的影响。该研究在70名计划进行输卵管结扎的产后患者中进行，这些患者体重在45至120千克之间，研究采用盲法。根据四个成串刺激（TOF）肌电图反应的图表记录来测量琥珀胆碱给药后的神经肌肉阻滞持续时间。在接受西咪替丁（A组）、雷尼替丁（B组）、法莫替丁（C组）和对照组（E组）的患者中，从95%阻滞开始到25%恢复的时间（“阻滞时间”）没有显著差异。然而，接受琥珀胆碱和甲氧氯普胺的患者（D组）的神经肌肉阻滞时间延长。
