替代药物与预防性血小板输注用于预防化疗或干细胞移植后血液系统疾病患者出血的比较
Alternative agents versus prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation.
作者信息
Estcourt Lise J, Gregg Richard, Stanworth Simon, Doree Carolyn, Trivella Marialena, Murphy Michael F, Tinmouth Alan
机构信息
Haematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.
Department of Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
出版信息
Cochrane Database Syst Rev. 2014(3). doi: 10.1002/14651858.CD010982.
Abstract
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine whether alternative agents (e.g. artificial platelet substitutes, platelet-poor plasma, fibrinogen, rFVIIa, thrombopoietin mimetics) are as effective and safe as the use of platelet transfusions for the prevention of bleeding (prophylactic platelet transfusion) in patients with haematological disorders who are undergoing myelosuppressive chemotherapy or stem cell transplantation. Antifibrinolytics (lysine analogues) will not be included in this review because they have been the focus of another Cochrane review (Wardrop 2013).
摘要
这是一项综述的方案，没有摘要。目标如下：确定在接受骨髓抑制性化疗或干细胞移植的血液系统疾病患者中，替代药物（如人工血小板替代品、少血小板血浆、纤维蛋白原、重组活化凝血因子VII、血小板生成素模拟物）在预防出血方面（预防性血小板输注）是否与使用血小板输注一样有效和安全。抗纤维蛋白溶解剂（赖氨酸类似物）不纳入本综述，因为它们是另一篇Cochrane综述（Wardrop，2013年）的重点内容。
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本文引用的文献
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Transfusion. 2014 Apr;54(4):1166-79. doi: 10.1111/trf.12441. Epub 2013 Oct 10.
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Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders.抗纤溶药物（赖氨酸类似物）用于预防血液系统疾病患者出血。
Cochrane Database Syst Rev. 2013 Jul 29(7):CD009733. doi: 10.1002/14651858.CD009733.pub2.
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A no-prophylaxis platelet-transfusion strategy for hematologic cancers.无预防性血小板输注策略用于血液系统恶性肿瘤。
N Engl J Med. 2013 May 9;368(19):1771-80. doi: 10.1056/NEJMoa1212772.
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Transfusion. 2013 Oct;53(10):2230-42. doi: 10.1111/trf.12175. Epub 2013 Apr 3.
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