小鼠中的ENU诱变
ENU mutagenesis in the mouse.
作者信息
Stottmann Rolf, Beier David
机构信息
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
出版信息
Curr Protoc Mouse Biol. 2014 Jun 16;4(2):25-35. doi: 10.1002/9780470942390.mo140029.
Abstract
This article describes the treatment of laboratory mice with the mutagen N-ethyl-N-nitrosourea (ENU) to induce very highly increased rates of mutation throughout the genome. Further, it describes several popular mating schemes designed to produce animals displaying phenotypes associated with the induced mutations.
摘要
本文描述了用诱变剂N-乙基-N-亚硝基脲（ENU）处理实验小鼠，以诱导全基因组范围内的突变率大幅提高。此外，还描述了几种常见的交配方案，旨在培育出表现出与诱导突变相关表型的动物。
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