Akboga Mehmet Kadri, Canpolat Ugur, Balci Kevser Gulcihan, Akyel Ahmet, Sen Fatih, Yayla Cagri, Cay Serkan, Aras Dursun, Aydogdu Sinan
Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey
Department of Cardiology, Turkiye Yuksek Ihtisas Training and Research Hospital, Ankara, Turkey.
Angiology. 2016 Jan;67(1):21-6. doi: 10.1177/0003319715574625. Epub 2015 Feb 26.
Previous studies showed that both inflammation and platelets have a role in development of slow coronary flow (SCF). Platelet to lymphocyte ratio (PLR) as an emerging inflammatory indicator was significantly associated with adverse cardiovascular events. Therefore, we aimed to assess the relationship between PLR and SCF. Patients who had angiographically normal coronary arteries were enrolled in this retrospective study (n = 221 as SCF group and n = 293 as control group). Patients who had thrombolysis in myocardial infarction frame counts (TFC) above the normal cutoffs were considered to have SCF. Both PLR and C-reactive protein (CRP) were significantly higher in the SCF group. In correlation analysis, PLR has a significantly positive correlation with the left anterior descending artery TFC (P = .001), circumflex artery TFC (P < .001), right coronary artery TFC (P < .001), and serum CRP level (P < .001). In multiple logistic regression analysis, PLR was independently associated with presence of SCF (odds ratio: 1.014, P < .001). In conclusion, higher PLR levels were significantly and independently related to the presence of SCF. Besides, PLR was positively correlated with serum CRP level as a conventional marker for systemic inflammation.
既往研究表明，炎症和血小板均在冠状动脉血流缓慢（SCF）的发生发展中起作用。血小板与淋巴细胞比值（PLR）作为一种新兴的炎症指标，与不良心血管事件显著相关。因此，我们旨在评估PLR与SCF之间的关系。本回顾性研究纳入了冠状动脉造影正常的患者（SCF组221例，对照组293例）。心肌梗死溶栓帧数（TFC）高于正常临界值的患者被认为患有SCF。SCF组的PLR和C反应蛋白（CRP）均显著更高。在相关性分析中，PLR与左前降支动脉TFC（P = 0.001）、回旋支动脉TFC（P < 0.001）、右冠状动脉TFC（P < 0.001）及血清CRP水平（P < 0.001）呈显著正相关。在多因素逻辑回归分析中，PLR与SCF的存在独立相关（比值比：1.014，P < 0.001）。总之，较高的PLR水平与SCF的存在显著且独立相关。此外，PLR与作为全身炎症传统标志物的血清CRP水平呈正相关。
