Yu Shasha, Guo Xiaofan, Li GuangXiao, Yang Hongmei, Zheng Liqiang, Sun Yingxian
Department of Cardiology, First Hospital of China Medical University, Shenyang, China.
Department of Clinical Epidemiology, Institute of Cardiovascular Diseases, First Hospital of China Medical University, Shenyang, China.
Front Cardiovasc Med. 2021 Mar 12;8:583320. doi: 10.3389/fcvm.2021.583320. eCollection 2021.
This study intended to use two novel inflammatory indicators: lymphocyte to high-density lipoprotein cholesterol ratio (LHR) and platelet to lymphocyte ratio (PLR), to predict newly diagnosed metabolic syndrome (MetS) among subjects from rural Northeast China. Adult participants without MetS at baseline ( = 4,980, age = 52.65 ± 10.21 years; 51.9% men) were originated from the Northeast China Rural Cardiovascular Health Study (NCRCHS). LHR (Q1: ≤1.04; Q2: 1.04-1.35; Q3: 1.35-1.79; Q4: ≥1.79) and PLR (Q1: ≤78.50; Q2: 78.50-107.27; Q3: 107.27-140.00; Q4: ≥140.00) were divided in quartile. After 4.66-year follow-up, 1,194 subjects were diagnosed MetS (cumulative incidence 24.0; 25.8% for female and 22.3% for male, = 0.002). Newly diagnosed MetS had higher value of hemoglobin and platelet count compared to those without MetS. As for LHR, from Q1 to Q4, there were increasing value of waist circumference (WC), serum triglycerides (TG), rates of current smoking and drinking whereas decreasing value of HDL-C. However, for PLR, rates of current smoking and drinking significantly decreased from Q1 to Q4. Similarly, the value of WC and TG showed a decreasing trend. In a logistic regression analysis, after adjusted for possible confounders, LHR [OR (95% CI) Q2: 1.13 (0.86, 1.48); OR (95% CI) Q3: 1.23 (0.94, 1.61); OR (95% CI) Q4: 1.57(1.20, 2.06)] but not PLR was effective predictor of newly diagnosed MetS among rural Chinese. MetS had closed relationship with inflammation among subjects from rural China. As a novel marker of inflammation, LHR but not PLR might be an effective predictor of newly diagnosed MetS and should be widely used in the epidemiological study.
淋巴细胞与高密度脂蛋白胆固醇比值（LHR）和血小板与淋巴细胞比值（PLR），以预测中国东北农村地区受试者新诊断的代谢综合征（MetS）。来自中国东北农村心血管健康研究（NCRCHS）的成年参与者在基线时无MetS（n = 4980，年龄 = 52.65±10.21岁；男性占51.9%）。LHR（Q1：≤1.04；Q2：1.04 - 1.35；Q3：1.35 - 1.79；Q4：≥1.79）和PLR（Q1：≤78.50；Q2：78.50 - 107.27；Q3：107.27 - 140.00；Q4：≥140.00）被分为四分位数。经过4.66年的随访，1194名受试者被诊断为MetS（累积发病率24.0；女性为25.8%，男性为22.3%，P = 0.002）。新诊断为MetS的患者血红蛋白和血小板计数的值高于未患MetS的患者。至于LHR，从Q1到Q4，腰围（WC）、血清甘油三酯（TG）、当前吸烟和饮酒率的值增加，而高密度脂蛋白胆固醇（HDL - C）的值降低。然而，对于PLR，当前吸烟和饮酒率从Q1到Q4显著降低。同样，WC和TG的值呈下降趋势。在逻辑回归分析中，在调整可能的混杂因素后，LHR [比值比（95%可信区间）Q2：1.13（0.86，1.48）；比值比（95%可信区间）Q3：1.23（0.94，1.61）；比值比（95%可信区间）Q4：1.57（1.20，2.06）] 是中国农村新诊断MetS的有效预测指标，而PLR不是。在中国农村受试者中，MetS与炎症密切相关。作为一种新型炎症标志物，LHR而非PLR可能是新诊断MetS的有效预测指标，应在流行病学研究中广泛应用。
