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弱势群体中慢性肾脏病预防项目的必要性。

Need for chronic kidney disease prevention programs in disadvantaged populations.

作者信息

Perico Norberto, Remuzzi Giuseppe

机构信息

Clinical Research Center for Rare Diseases "Aldo e Cele Dacco" - IRCCS Istituto di Ricerche Farmacologiche Mario Negri, and Department of Medicine, Unit of Nephrology and Dialysis, A.O. Papa Giovanni XXIII, Bergamo, Italy.

出版信息

Clin Nephrol. 2015;83(7 Suppl 1):42-8. doi: 10.5414/cnp83s042.

Abstract

Chronic kidney disease (CKD) is a key determinant of the poor health outcomes for major non-communicable diseases that are the leading cause of death in the world. CKD is a worldwide threat to public health, but the size of the problem is not fully appreciated. Early recognition of CKD and concomitant co-morbid conditions, can potentially slow progression to renal failure, increase longevity, improve quality of life, and reduce healthcare costs. Although screening programmes are attractive, there is no consensus yet on which individuals should be prioritized (high-risk group for CKD, or general population) especially in resourcepoor regions. In these settings there is not a unique blueprint of screening strategy, so that the approaches should be adapted on single-nation conditions and socioeconomic status. Effective multimodal tools are available to prevent CKD by managing its risk factors, and to slow or even halt disease progression to end-stage renal failure, as well as reduce the associated risk of cardiovascular morbidity and mortality. They can be adapted even to the poorest populations who are at the highest risk of CKD. Where management strategies have been implemented, the incidence of end-stage renal disease (ESRD) has been reduced. The hope is that all these efforts will assist to make major advances in addressing the neglected aspect of renal health, especially of poor and disadvantaged populations worldwide. Beside saving young lives, such action would minimize the present health inequity that arises mainly from the unaffordable cost of renal replacement therapy if ESRD is not prevented.

摘要

慢性肾脏病(CKD)是导致全球主要死因的重大非传染性疾病健康状况不佳的关键决定因素。CKD是对全球公共卫生的一大威胁,但该问题的严重程度尚未得到充分认识。早期识别CKD及其伴随的合并症,有可能减缓肾衰竭进程、延长寿命、提高生活质量并降低医疗成本。尽管筛查项目很有吸引力,但对于哪些个体应被优先筛查(CKD高危人群还是普通人群)尚未达成共识,尤其是在资源匮乏地区。在这些情况下,没有单一的筛查策略蓝图,因此筛查方法应根据各国国情和社会经济状况进行调整。有效的多模式工具可用于通过管理CKD的风险因素来预防CKD,并减缓甚至阻止疾病进展至终末期肾衰竭,同时降低心血管疾病发病和死亡的相关风险。这些工具甚至可以适用于CKD风险最高的最贫困人群。在实施了管理策略的地方,终末期肾病(ESRD)的发病率有所降低。希望所有这些努力将有助于在解决肾脏健康被忽视的方面取得重大进展,尤其是全球贫困和弱势群体的肾脏健康。除了挽救年轻人的生命外,此类行动还将最大限度地减少目前主要因ESRD未得到预防而导致的肾脏替代治疗费用高昂所产生的健康不平等现象。

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