胶原介导的二次谐波产生的近红外触发药物递送。
NIR-triggered drug delivery by collagen-mediated second harmonic generation.
机构信息
Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
出版信息
Adv Healthc Mater. 2015 Jun 3;4(8):1159-63. doi: 10.1002/adhm.201400768. Epub 2015 Feb 27.
Second harmonic generation is a process through which nonlinear materials such as collagen can absorb two photons and scatter one with twice the energy. Collagen upconverts 730 nm (near-IR) to 365 nm (UV) through second harmonic generation, which cleaves a molecule bound to collagen via a UV-sensitive linker.
二次谐波产生是一种非线性材料（如胶原蛋白）吸收两个光子并散射出一个两倍能量光子的过程。胶原蛋白通过二次谐波产生将 730nm（近红外）上转换为 365nm（紫外），从而通过紫外光敏感的连接物切割与胶原蛋白结合的分子。
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