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局部麻醉药控释材料。

Materials for Controlled Release of Local Anesthetics.

机构信息

Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

出版信息

ChemMedChem. 2023 Jun 1;18(11):e202300009. doi: 10.1002/cmdc.202300009. Epub 2023 Apr 18.

DOI:10.1002/cmdc.202300009
PMID:37070644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11372721/
Abstract

Controlled release systems for prolonged duration local anesthesia have long been an area of research interest, and now are entering clinical practice, in part driven by the opioid epidemic. We discuss the design considerations and material properties of systems for controlled release of local anesthetics, from relatively simple systems to covalent binding of drugs to materials and delivery triggered by external stimuli.

摘要

控释系统用于延长局部麻醉的持续时间一直是研究的重点，并且由于阿片类药物流行，现在开始进入临床实践。我们讨论了局部麻醉剂控释系统的设计考虑因素和材料特性，从相对简单的系统到药物与材料的共价结合以及外部刺激触发的输送。

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Materials for Controlled Release of Local Anesthetics.局部麻醉药控释材料。
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A hybrid nanoparticle-protein hydrogel system for prolonged local anesthesia.一种用于延长局部麻醉的混合纳米颗粒-蛋白质水凝胶系统。
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Theranostics. 2022 Jun 21;12(11):4904-4921. doi: 10.7150/thno.74845. eCollection 2022.
2
Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol.脂质体：结构、生物医学应用及稳定性参数，重点关注胆固醇
Front Bioeng Biotechnol. 2021 Sep 9;9:705886. doi: 10.3389/fbioe.2021.705886. eCollection 2021.
3
Synergy in Nanomedicine: What It Is Not, and What It Might Be.
纳米医学中的协同作用：不是什么，可能是什么。
Nano Lett. 2021 Jul 14;21(13):5457-5460. doi: 10.1021/acs.nanolett.1c01894. Epub 2021 Jun 29.
4
Liposomal Bupivacaine.脂质体布比卡因
Anesthesiology. 2021 Feb 1;134(2):139-142. doi: 10.1097/ALN.0000000000003658.
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Exparel for Postoperative Pain Management: a Comprehensive Review.用于术后疼痛管理的Exparel：一项全面综述。
Curr Pain Headache Rep. 2020 Oct 23;24(11):73. doi: 10.1007/s11916-020-00905-4.
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Opportunities and challenges in commercial pharmaceutical liposome applications.商业制药脂质体应用的机遇与挑战。
Adv Drug Deliv Rev. 2020;154-155:2-12. doi: 10.1016/j.addr.2020.07.016. Epub 2020 Jul 22.
7
Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia.光触发从大分子前药中释放常规局部麻醉剂，用于按需局部麻醉。
Nat Commun. 2020 May 8;11(1):2323. doi: 10.1038/s41467-020-16177-w.
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The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats.男性和女性大鼠局部麻醉制剂的神经阻滞持续时间。
Pharm Res. 2019 Nov 8;36(12):179. doi: 10.1007/s11095-019-2715-3.
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Anesth Analg. 2019 Sep;129(3):709-717. doi: 10.1213/ANE.0000000000004108.
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Nat Commun. 2019 Jun 12;10(1):2566. doi: 10.1038/s41467-019-10296-9.