Spyratos F, Maudelonde T, Brouillet J P, Brunet M, Defrenne A, Andrieu C, Hacene K, Desplaces A, Rouëssé J, Rochefort H
Centre René Huguenin, Saint-Cloud, France.
Lancet. 1989 Nov 11;2(8672):1115-8. doi: 10.1016/s0140-6736(89)91487-6.
122 patients with primary breast cancer were followed-up for a median of 4.6 years after surgery. The concentration of cathepsin D in tumour cytosol was strongly related to both metastasis-free survival and disease-free survival and was independent of nine conventional prognostic indices. Cathepsin D assay may prove particularly useful in identifying women who, though without lymph node involvement at presentation, are at high risk of metastatic disease.
