Schneeberger Marc, Gomez-Valadés Alicia G, Ramirez Sara, Gomis Ramon, Claret Marc
Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona, Spain ; Department of Endocrinology and Nutrition, School of Medicine, Hospital Clínic, University of Barcelona Barcelona, Spain ; CIBER de Diabetes y Enfermedades Metabólicas Asociadas Barcelona, Spain.
Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona, Spain ; CIBER de Diabetes y Enfermedades Metabólicas Asociadas Barcelona, Spain.
Front Neurosci. 2015 Feb 12;9:41. doi: 10.3389/fnins.2015.00041. eCollection 2015.
The hypothalamus is a crucial central nervous system area controlling appetite, body weight and metabolism. It consists in multiple neuronal types that sense, integrate and generate appropriate responses to hormonal and nutritional signals partly by fine-tuning the expression of specific batteries of genes. However, the mechanisms regulating these neuronal gene programmes in physiology and pathophysiology are not completely understood. MicroRNAs (miRNAs) are key regulators of gene expression that recently emerged as pivotal modulators of systemic metabolism. In this article we will review current evidence indicating that miRNAs in hypothalamic neurons are also implicated in appetite and whole-body energy balance control.
下丘脑是控制食欲、体重和新陈代谢的关键中枢神经系统区域。它由多种神经元类型组成，这些神经元通过微调特定基因组合的表达，感知、整合并对激素和营养信号产生适当反应。然而，在生理和病理生理过程中调节这些神经元基因程序的机制尚未完全明确。微小RNA（miRNA）是基因表达的关键调节因子，最近已成为全身代谢的关键调节因子。在本文中，我们将综述当前的证据，这些证据表明下丘脑神经元中的miRNA也参与食欲和全身能量平衡的控制。
