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一例进展为莱姆心肌炎的未识别皮疹:关于莱姆病的重要特征及建议

An Unrecognized Rash Progressing to Lyme Carditis: Important Features and Recommendations Regarding Lyme Disease.

作者信息

Lee Shawn, Singla Montish

机构信息

1St. George's University, St. George's, Grenada; and 2Mount Sinai St. Luke's Roosevelt Hospital.

出版信息

Am J Ther. 2016 Mar-Apr;23(2):e566-9. doi: 10.1097/MJT.0000000000000217.

Abstract

We present a case report of 46-year-old man with no medical history, who complained of extreme fatigue, near-syncope, and palpitations. He initially presented in complete heart block. A transvenous pacemaker was placed in the emergency department, and he was started empirically on Ceftriaxone for Lyme disease. He was admitted and over the course of the next few days, his rhythm regressed to Mobitz type I first-degree atrioventricular block and then to normal sinus rhythm. This case report highlights some important features regarding Lyme carditis, a rare presentation of early disseminated Lyme disease (seen in a few weeks to months after the initial tick bite). In 25%-30% of patients, the characteristic targetoid rash may not be seen, a likely culprit of the disease not being detected early and progressing to disseminated disease. The most common cardiac complaint of Lyme disease is palpitations, occurring in 6.6% of patients, which may not accurately reflect progression into disseminated Lyme disease because it is a nonspecific finding. Conduction abnormality, occurring in 1.8% of patients, is a more specific finding of Borrelia invading cardiac tissue. Finally, this case report highlights a recommendation that patients with confirmed Lyme disease or those presenting with cardiac abnormalities or symptoms who have an atypical profile for a cardiac event should be screened with a 12-lead electrocardiogram, Lyme serology, and be considered for antibiotic therapy with the possibility of temporary pacing.

摘要

我们报告一例46岁男性病例,该患者无病史,主诉极度疲劳、近乎晕厥和心悸。他最初表现为完全性心脏传导阻滞。在急诊科放置了经静脉起搏器,并经验性地给予头孢曲松治疗莱姆病。他被收治入院,在接下来的几天里,他的心律退化为莫氏I型一度房室传导阻滞,然后恢复为正常窦性心律。本病例报告突出了莱姆病心肌炎的一些重要特征,这是早期播散性莱姆病的一种罕见表现(在初次蜱叮咬后数周或数月出现)。在25%-30%的患者中,可能看不到特征性的靶形皮疹,这可能是疾病未被早期发现并进展为播散性疾病的一个原因。莱姆病最常见的心脏症状是心悸,见于6.6%的患者,由于这是一个非特异性表现,可能无法准确反映疾病进展为播散性莱姆病。传导异常见于1.8%的患者,是伯氏疏螺旋体侵入心脏组织的一个更具特异性的表现。最后,本病例报告强调一项建议,即确诊莱姆病的患者或出现心脏异常或症状且心脏事件表现不典型的患者,应进行12导联心电图、莱姆病血清学检查,并考虑进行抗生素治疗,可能需要临时起搏。

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