Winter G P
MRC Laboratory of Molecular Biology, Cambridge, U.K.
Philos Trans R Soc Lond B Biol Sci. 1989 Aug 31;324(1224):537-46; discussion 547. doi: 10.1098/rstb.1989.0066.
The antibody molecule is a therapeutic agent, designed by nature to bind to a wide range of antigen molecules and to trigger effector functions, such as complement lysis and cell-mediated killing. The genes encoding antibodies can be manipulated in vitro, allowing the binding sites for antigen and effector molecules to be dissected, and new properties to be engineered. The future for the application of engineered antibodies in medicine is reviewed in the context of the past century.
抗体分子是一种治疗剂，由自然设计用于结合多种抗原分子并触发效应功能，如补体裂解和细胞介导的杀伤。编码抗体的基因可以在体外进行操作，从而剖析抗原和效应分子的结合位点，并设计新的特性。本文在过去一个世纪的背景下综述了工程抗体在医学应用中的未来。
