Isozaki Tetsuro, Yamada Shigeru, Shiomi Miho, Yasuda Shigeo, Kamada Tadashi, Tsujii Hirohiko, Matsubara Hisahiro
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences.
Gan To Kagaku Ryoho. 2014 Nov;41(12):2387-9.
A 55-year-old man, with a prior diagnosis of primary malignant melanoma of the esophagus, had undergone esophagectomy 6 years prior. During the postoperative follow-up, a flat tumor with black pigmentation, about 2 cm in diameter, was detected during upper gastrointestinal endoscopy. A pathological examination of the biopsy specimen showed a recurrent malignant melanoma. He underwent heavy ion radiotherapy for the tumor, and it disappeared after 6 months. Subsequently, a mediastinal lymph node metastasis was detected a year after radiotherapy. He received heavy ion radiotherapy for that tumor, and it was reduced in size a year after radiotherapy. At present, the patient is alive, 13 years after the initial radiotherapy. Although malignant melanoma is generally considered to be a radioresistant cancer, heavy ion radiotherapy led to a favorable outcome. This is the first reported case of heavy ion radiotherapy for treating the recurrence of a primary malignant melanoma of the esophagus.
一名55岁男性，既往诊断为原发性食管恶性黑色素瘤，6年前接受了食管切除术。术后随访期间，上消化道内镜检查发现一个直径约2 cm、有黑色色素沉着的扁平肿瘤。活检标本的病理检查显示为复发性恶性黑色素瘤。他接受了针对该肿瘤的重离子放疗，6个月后肿瘤消失。随后，放疗一年后检测到纵隔淋巴结转移。他接受了针对该肿瘤的重离子放疗，放疗一年后肿瘤缩小。目前，患者在初次放疗后已存活13年。尽管恶性黑色素瘤通常被认为是一种抗辐射癌症，但重离子放疗带来了良好的结果。这是首例报道的采用重离子放疗治疗原发性食管恶性黑色素瘤复发的病例。
