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[1例晚期胃癌伴施尼茨勒转移经联合化疗有效治疗后长期生存的病例]

[A case of long-term survival of advanced gastric cancer with schnitzler metastasis effectively treated with combination chemotherapy].

作者信息

Wada Yuma, Okada Kazuyuki, Ebisui Chikara, Yanagisawa Tetsu, Okamura Shu, Fukuchi Nariaki, Murata Kouhei, Yokouchi Hideoki, Kinuta Masakatsu

机构信息

Dept. of Surgery, Suita Municipal Hospital.

出版信息

Gan To Kagaku Ryoho. 2014 Nov;41(12):2411-3.

Abstract

A 66-year-old woman was diagnosed with unresectable advanced gastric cancer with Schnitzler metastasis in January 2012. She was treated with combination chemotherapy comprising S-1 and docetaxel (DTX). However, in January 2013, after 13 courses of treatment, a computed tomography (CT) indicated peritoneal dissemination growth. The chemotherapy regimen was changed to a combination of S-1 and irinotecan (CPT-11), but after a single course of treatment the patient complained of stomachaches and vomiting. The patient developed ileus from the stenosis of the rectum, and a transanal ileus tube was used to decompress the bowel tract. Due to the patient's poor general condition, a metallic stent was inserted, and she could resume eating. Thereafter, we changed the chemotherapy regimen to weekly paclitaxel (PTX). However, 1 year and 4 months after starting treatment she died of regrowth of the peritoneal disseminating lesions. We recommend a combination of chemotherapy and metallic stent placement to improve quality of life and long-term survival.

摘要

一名66岁女性于2012年1月被诊断为伴有施尼茨勒转移的不可切除晚期胃癌。她接受了由S-1和多西他赛(DTX)组成的联合化疗。然而,在2013年1月,经过13个疗程的治疗后,计算机断层扫描(CT)显示腹膜播散性生长。化疗方案改为S-1和伊立替康(CPT-11)联合,但在一个疗程的治疗后,患者出现腹痛和呕吐。患者因直肠狭窄发展为肠梗阻,并使用经肛门肠梗阻导管对肠道进行减压。由于患者一般状况较差,插入了金属支架,她能够恢复进食。此后,我们将化疗方案改为每周一次的紫杉醇(PTX)。然而,在开始治疗1年零4个月后,她死于腹膜播散性病变的复发。我们建议联合化疗和放置金属支架以提高生活质量和长期生存率。

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