Keen Larry, Turner Arlener D
Department of Psychology, Virginia State University, 1 Hayden Drive, PO Box 9079, Petersburg, VA, 23806, USA,
J Behav Med. 2015 Jun;38(3):527-34. doi: 10.1007/s10865-015-9625-6. Epub 2015 Mar 3.
It is unknown how lifetime marijuana use affects different proinflammatory cytokines. The purpose of the current study is to explore potential differential effects of lifetime marijuana use on interleukin-1 alpha (IL-1α) and tumor necrosis factor (TNF) in a community based sample. Participants included 168 African American adults (51 % female, median age = 47 years). Upon study entry, blood was drawn and the participants completed questions regarding illicit drug use history whose answers were used to create three groups: lifetime non-drug users (n = 77), lifetime marijuana only users (n = 46) and lifetime marijuana and other drug users (n = 45). In the presence of demographic and physiological covariates, non-drug users were approximately two times more likely (AOR 2.73, CI 1.18, 6.31; p = .03) to have higher TNF levels than marijuana only users. Drug use was not associated with IL-1α. The influence of marijuana may be selective in nature, potentially localizing around innate immunity and the induction of cellular death.
终生使用大麻如何影响不同的促炎细胞因子尚不清楚。本研究的目的是在一个基于社区的样本中探索终生使用大麻对白介素-1α（IL-1α）和肿瘤坏死因子（TNF）的潜在差异影响。参与者包括168名非裔美国成年人（51%为女性，年龄中位数 = 47岁）。在研究开始时，采集血液样本，参与者回答了关于非法药物使用史的问题，这些答案被用于创建三组：终生非药物使用者（n = 77）、终生仅使用大麻者（n = 46）和终生使用大麻及其他药物者（n = 45）。在存在人口统计学和生理协变量的情况下，非药物使用者的TNF水平高于仅使用大麻者的可能性约为两倍（调整后比值比2.73，置信区间1.18, 6.31；p = 0.03）。药物使用与IL-1α无关。大麻的影响可能具有选择性，可能集中在固有免疫和细胞死亡诱导方面。
