Siepler J K, Trudeau W, Petty D E
University of California, Davis School of Medicine, Sacramento, 95817.
DICP. 1989 Oct;23(10 Suppl):S40-3. doi: 10.1177/1060028089023s1007.
Certain clinical situations require the use of a histamine2 (H2)-receptor antagonist to reduce gastric-acid volume and concentration or an antacid to act as a buffering agent. Presently, there are three H2-receptor antagonists available for iv use: cimetidine, ranitidine, and famotidine. Conventional therapy dictates that the H2-receptor antagonist be given by intermittent intravenous infusion, resulting in peaks and valleys of acid secretory control. Antacids, although capable of providing adequate gastric acidity control, must be administered frequently, often hourly, and thus require excessive nursing time. Presented here is a review of the rationale for the use of an H2-receptor antagonist by continuous infusion.
某些临床情况需要使用组胺2（H2）受体拮抗剂来减少胃酸的量和浓度，或者使用抗酸剂作为缓冲剂。目前，有三种H2受体拮抗剂可供静脉注射使用：西咪替丁、雷尼替丁和法莫替丁。传统疗法规定，H2受体拮抗剂需通过间歇性静脉输注给药，从而导致胃酸分泌控制出现高峰和低谷。抗酸剂虽然能够充分控制胃酸度，但必须频繁给药，通常每小时一次，因此需要大量的护理时间。本文综述了持续输注H2受体拮抗剂的使用原理。
