Bachmann K, Sullivan T J, Jauregui L
Center for Applied Pharmacology, University of Toledo, Ohio.
J Clin Pharmacol. 1993 Dec;33(12):1219-24. doi: 10.1002/j.1552-4604.1993.tb03923.x.
Continuous infusions of any given H2-blocking drug have uniformly been found to be superior to intermittent infusions of the same H2-blocking drug in sustaining elevations in gastric pH. Comparisons of intermittent and continuous infusions among different H2-blocking drugs have heretofore not been made. Owing to its greater potency and longer half-life, the authors were interested in determining whether intermittent infusions of famotidine might be as effective as continuous infusions of ranitidine in sustaining elevations of gastric pH. The effectiveness of a continuous intravenous infusion of ranitidine (6.25 mg/hr) was compared with the effectiveness of intermittent intravenous infusions of famotidine (20 mg every 12 hours) in sustaining gastric pH above 4.0 in 18 young, healthy adult male subjects using a randomized two-way cross-over design. Gastric pH was continuously monitored for 24 hours. The intermittent famotidine regimen was determined to be as effective as the continuous ranitidine regimen with respect to the following parameters: (1) the percentage of the 24-hour dosing period during which gastric pH exceeded 4.0; (2) the area under the pH > or = 4 versus time curve; and (3) median gastric pH.
在维持胃内pH值升高方面，任何一种给定的H2受体阻断药持续输注均被一致认为优于同一H2受体阻断药的间歇输注。不同H2受体阻断药之间的间歇输注与持续输注的比较此前尚未进行。由于法莫替丁效力更强、半衰期更长，作者们感兴趣于确定法莫替丁间歇输注在维持胃内pH值升高方面是否可能与雷尼替丁持续输注一样有效。采用随机双向交叉设计，比较了18名年轻健康成年男性受试者中持续静脉输注雷尼替丁（6.25毫克/小时）与间歇静脉输注法莫替丁（每12小时20毫克）在维持胃内pH值高于4.0方面的有效性。连续24小时监测胃内pH值。就以下参数而言，间歇法莫替丁方案被确定与持续雷尼替丁方案一样有效：（1）胃内pH值超过4.0的24小时给药期百分比；（2）pH≥4与时间曲线下面积；以及（3）胃内pH值中位数。
