Cheng-Ching Esteban, Jones Stephen, Hui Ferdinand K, Man Shumei, Gilden Don, Bhimraj Adarsh, Uchino Ken
Department of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
J Neurol Sci. 2015 Apr 15;351(1-2):168-173. doi: 10.1016/j.jns.2015.02.017. Epub 2015 Feb 16.
Contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (VZV) vasculopathy. We retrospectively reviewed a database of patients with virologically-verified VZV vasculopathy, who underwent initial and follow-up HRMR between April 2011 and May 2014. Six patients were identified. Baseline demographic and clinical characteristics were collected, including stroke risk factors, history of VZV-related disorders, neurological presentation, course and antiviral treatment. Initial HRMR in patients with VZV vasculopathy demonstrated various patterns of stenosis, vessel wall thickening and enhancement, predominantly in terminal internal carotid artery segments and the M1 segment of the middle cerebral arteries. Follow-up HRMR showed improvement of stenosis, with reduced vessel wall thickening and enhancement at multiple times after treatment. HRMR has the potential to assist in diagnosis and treatment of VZV vasculopathy.
对比增强血管壁成像高分辨率磁共振成像（HRMR）已显示，在包括水痘带状疱疹病毒（VZV）血管病变在内的多种颅内血管病变中存在血管壁增厚和强化。我们回顾性分析了2011年4月至2014年5月期间接受初次和随访HRMR检查、经病毒学证实为VZV血管病变患者的数据库。共识别出6例患者。收集了基线人口统计学和临床特征，包括中风危险因素、VZV相关疾病史、神经系统表现、病程及抗病毒治疗情况。VZV血管病变患者的初次HRMR显示出各种狭窄、血管壁增厚和强化模式，主要位于颈内动脉终末段和大脑中动脉M1段。随访HRMR显示狭窄有所改善，治疗后多次复查时血管壁增厚和强化减轻。HRMR有潜力辅助VZV血管病变的诊断和治疗。
