Mandai Kenji, Rikitake Yoshiyuki, Mori Masahiro, Takai Yoshimi
Division of Pathogenetic Signaling, Kobe University Graduate School of Medicine, Kobe, Japan; CREST, Japan Science and Technology Agency, Kobe, Japan.
CREST, Japan Science and Technology Agency, Kobe, Japan; Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Curr Top Dev Biol. 2015;112:197-231. doi: 10.1016/bs.ctdb.2014.11.019. Epub 2015 Feb 12.
Nectins and nectin-like molecules (Necls)/Cadms are Ca(2+)-independent immunoglobulin superfamily cell adhesion molecules, expressed in most cell types. Nectins mediate not only homotypic but also heterotypic cell-cell adhesion, in contrast to classic cadherins which participate only in homophilic adhesion. Nectins and Necls function in organogenesis of the eye, inner ear, tooth, and cerebral cortex and in a variety of developmental processes including spermatogenesis, axon guidance, synapse formation, and myelination. They are also involved in various diseases, such as viral infection, hereditary ectodermal dysplasia, Alzheimer's disease, autism spectrum disorder, and cancer. Thus, nectins and Necls are crucial for both physiology and pathology. This review summarizes recent advances in research on these cell adhesion molecules in development and pathogenesis.
NECTIN蛋白和NECTIN样分子（Necls）/钙黏附分子（Cadms）是不依赖钙离子的免疫球蛋白超家族细胞黏附分子，在大多数细胞类型中均有表达。与仅参与同型黏附的经典钙黏蛋白不同，NECTIN蛋白不仅介导同型细胞间黏附，还介导异型细胞间黏附。NECTIN蛋白和Necls在眼睛、内耳、牙齿和大脑皮层的器官发生以及包括精子发生、轴突导向、突触形成和髓鞘形成在内的各种发育过程中发挥作用。它们还与多种疾病有关，如病毒感染、遗传性外胚层发育不良、阿尔茨海默病、自闭症谱系障碍和癌症。因此，NECTIN蛋白和Necls对生理和病理过程都至关重要。本综述总结了这些细胞黏附分子在发育和发病机制方面的最新研究进展。
