Afadin-nectin 力量使其走向前沿。

Afadin-nectin forces its way to the front.

机构信息

Aix-Marseille University, Inserm, DyNaMo, Turing Centre of Living Systems, Marseille, France.

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine and Departments of Cell Biology and Biomedical Engineering, Yale University, New Haven, CT, USA.

出版信息

J Cell Biol. 2024 May 6;223(5). doi: 10.1083/jcb.202403177. Epub 2024 Apr 2.

DOI:10.1083/jcb.202403177

PMID:38563860

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10988649/

Abstract

Force transmission at cell-cell junctions critically regulates embryogenesis, tissue homeostasis, and diseases including cancer. The cadherin-catenin linkage has been considered the keystone of junctional force transmission, but new findings challenge this paradigm, arguing instead that the nectin-afadin linkage plays the more important role in mature junctions in the intestinal epithelium.

摘要

细胞连接的力传递对于胚胎发生、组织稳态以及包括癌症在内的疾病的发生具有至关重要的作用。钙黏蛋白-连环蛋白连接被认为是连接力传递的关键，但新的发现对这一观点提出了挑战，而是认为在成熟的肠道上皮细胞连接中，连接蛋白-粘着斑蛋白连接发挥了更重要的作用。