Beaufils M
Hôpital Tenon, Paris, France.
Am J Hypertens. 1989 Nov;2(11 Pt 2):233S-236S. doi: 10.1093/ajh/2.11.233s.
Renal hemodynamics of hypertensive patients are characterized by an increased renal vascular resistance (RVR), resulting in low renal plasma flow (RPF). Normal glomerular filtration rate (GFR) is maintained through an increased filtration fraction (FF). This pattern may have long term harmful consequences for the kidneys. Propranolol, given in the short- or long-term, lowers both RPF and GFR. Pindolol, as well as so called cardioselective beta-blockers and labetalol, alter renal hemodynamics only slightly, if not at all. In some studies, nadolol has been shown to increase RPF, leaving GFR unchanged. A new beta-blocker, tertatolol, seems to consistently increase RPF and GFR. These different renal actions of various beta-blockers are poorly explained. They may be, however, of clinical significance, in the short term for patients with already impaired renal function, and possibly over the long term for other hypertensive patients.
高血压患者的肾血流动力学特征为肾血管阻力（RVR）增加，导致肾血浆流量（RPF）降低。通过增加滤过分数（FF）来维持正常的肾小球滤过率（GFR）。这种模式可能对肾脏产生长期有害影响。短期或长期给予普萘洛尔会降低RPF和GFR。吲哚洛尔以及所谓的心脏选择性β受体阻滞剂和拉贝洛尔对肾血流动力学的影响即使有也很轻微。在一些研究中，纳多洛尔已被证明可增加RPF，而GFR保持不变。一种新的β受体阻滞剂，替他洛尔，似乎能持续增加RPF和GFR。各种β受体阻滞剂的这些不同肾脏作用难以解释。然而，它们可能具有临床意义，短期内对肾功能已受损的患者如此，长期来看对其他高血压患者可能也是如此。
