Samal Sangram K, Dash Mamoni, Shelyakova Tatiana, Declercq Heidi A, Uhlarz Marc, Bañobre-López Manuel, Dubruel Peter, Cornelissen Maria, Herrmannsdörfer Thomas, Rivas Jose, Padeletti Giuseppina, De Smedt Stefaan, Braeckmans Kevin, Kaplan David L, Dediu V Alek
†Consiglio Nazionale delle Ricerche-Institute for Nanostructured Materials, I-40129 Bologna-Roma, Italy.
‡Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, United States.
ACS Appl Mater Interfaces. 2015 Mar 25;7(11):6282-92. doi: 10.1021/acsami.5b00529. Epub 2015 Mar 10.
Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.
制备了集成磁性材料并具有磁梯度的磁性丝素蛋白（SFP）支架，以用于磁场辅助组织工程。通过浸涂法将磁性纳米颗粒（MNPs）引入SFP支架中，从而得到具有不同磁化强度的磁性SFP支架。磁性SFP支架表现出优异的热疗性能，在约100秒内温度可升高至8°C。这些支架对成骨细胞无毒，并改善了细胞粘附和增殖。这些发现表明，可以设计出具有有趣特性的定制磁化丝基生物材料，用于生物材料和组织工程应用。
