Morgan Rachel E, Chudasama Vijay, Moody Paul, Smith Mark E B, Caddick Stephen
Department of Chemistry, University College London, 20 Gordon Street, London, UK.
Org Biomol Chem. 2015 Apr 14;13(14):4165-8. doi: 10.1039/c5ob00130g. Epub 2015 Mar 4.
Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.
泛素化作为蛋白质的翻译后修饰，通过泛素或泛素链促进许多重要的细胞过程，具有极其重要的意义。在此，我们提出了一种简便的方法，即在温和条件下使用基于二溴马来酰亚胺和二溴哒嗪二酮的迈克尔受体来制备各种泛素缀合物。
