Palamar Joseph J, Acosta Patricia
Department of Population Health, New York University (NYU) Langone Medical Center, New York, NY, USA; Center for Drug Use and HIV Research, NYU College of Nursing, New York, NY, USA.
Department of Population Health, New York University (NYU) Langone Medical Center, New York, NY, USA.
Drug Alcohol Depend. 2015 Apr 1;149:194-202. doi: 10.1016/j.drugalcdep.2015.01.044. Epub 2015 Feb 11.
Synthetic cannabinoids are marketed as "legal highs" and have similar effects to cannabis (marijuana). Although prevalence of synthetic cannabinoid use is now declining in the US, use has been associated with tens of thousands of poisonings and hospitalizations, particularly among teens. It is important to examine which teens are at highest risk for use of these new, potentially deleterious drugs as they are understudied and continue to emerge.
Data were analyzed from a nationally representative sample of high school seniors in the Monitoring the Future study (2011-2013; Weighted N = 11,863; modal age: 18). Bivariable and multivariable models were used to delineate correlates of recent (12-month) synthetic cannabinoid use.
Ten percent reported any recent use and 3% reported more frequent use (used ≥ 6 times). Females were at low odds for use and going out 4-7 evenings per week for fun consistently increased odds of use. Black and religious students were at low odds of use until controlling for other drug use, and higher income increased odds of use until controlling for other drug use. Lifetime use of alcohol, cigarettes and other illicit drugs all robustly increased odds of use, but frequency of lifetime marijuana use was the strongest correlate with more frequent use further increasing odds of synthetic cannabinoid use. Only 0.5% of non-marijuana users reported use of synthetic cannabinoids.
This is among the first national studies to delineate correlates of synthetic cannabinoid use. Results can inform national and local efforts to prevent use and adverse consequences resulting from use.
合成大麻素作为“合法兴奋剂”销售,其效果与大麻( marijuana)相似。尽管美国合成大麻素的使用流行率目前正在下降,但使用合成大麻素已导致数万人中毒和住院,尤其是青少年。鉴于这些新型潜在有害药物研究不足且不断出现,研究哪些青少年使用这些药物的风险最高很重要。
对“监测未来”研究中具有全国代表性的高三学生样本(2011 - 2013年;加权N = 11,863;众数年龄:18岁)的数据进行分析。使用双变量和多变量模型来描述近期(12个月内)合成大麻素使用的相关因素。
10%的人报告近期有过使用,3%的人报告使用频率更高(使用≥6次)。女性使用的可能性较低,每周外出娱乐4 - 7个晚上会持续增加使用的可能性。在控制其他药物使用之前,黑人学生和有宗教信仰的学生使用的可能性较低,在控制其他药物使用之前,较高收入会增加使用的可能性。终生饮酒、吸烟和使用其他非法药物都会显著增加使用的可能性,但终生使用大麻的频率与更频繁使用的相关性最强,会进一步增加合成大麻素使用的可能性。只有0.5%的非大麻使用者报告使用过合成大麻素。
这是首批描述合成大麻素使用相关因素的全国性研究之一。研究结果可为全国和地方预防使用及使用带来的不良后果的工作提供参考。