Kuta J, Smetanová S, Benová D, Kořistková T, Machát J
Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Laboratory Specializing in Urinary Stones Analyses, Calculi®, Vránova 172, P.O. Box 20, 621 00, Brno, Czech Republic.
Environ Geochem Health. 2016 Feb;38(1):133-43. doi: 10.1007/s10653-015-9691-2. Epub 2015 Mar 4.
Monitoring of body burden of toxic elements is usually based on analysis of concentration of particular elements in blood, urine and/or hair. Analysis of these matrices, however, predominantly reflects short- or medium-term exposure to trace elements or pollutants. In this work, urinary stones were investigated as a matrix for monitoring long-term exposure to toxic and essential elements. A total of 431 samples of urinary calculi were subjected to mineralogical and elemental analysis by infrared spectroscopy and inductively coupled plasma mass spectrometry. The effect of mineralogical composition of the stones and other parameters such as sex, age and geographical location on contents of trace and minor elements is presented. Our results demonstrate the applicability of such approach and confirm that the analysis of urinary calculi can be helpful in providing complementary information on human exposure to trace metals and their excretion. Analysis of whewellite stones (calcium oxalate monohydrate) with content of phosphorus <0.6 % has been proved to be a promising tool for biomonitoring of trace and minor elements.
对有毒元素体内负荷的监测通常基于对血液、尿液和/或头发中特定元素浓度的分析。然而，对这些基质的分析主要反映的是短期或中期对微量元素或污染物的接触情况。在这项研究中，对尿结石作为监测长期接触有毒和必需元素的一种基质进行了调查。总共431份尿结石样本通过红外光谱和电感耦合等离子体质谱进行了矿物学和元素分析。展示了结石的矿物学组成以及性别、年龄和地理位置等其他参数对痕量和微量元素含量的影响。我们的结果证明了这种方法的适用性，并证实尿结石分析有助于提供关于人类接触痕量金属及其排泄的补充信息。已证明对磷含量<0.6%的水草酸钙结石（一水合草酸钙）进行分析是痕量和微量元素生物监测的一种有前景的工具。
