Deng Gang, Ma Libin, Meng Qi, Ju Xiang, Jiang Kang, Jiang Peiwu, Yu Zhijian
Department of Urology, The First People's Hospital of Hangzhou, 216 Huansha Road, Hangzhou, 310006, Zhejiang, China.
Department of Nephrology, The First People's Hospital of Hangzhou, 216 Huansha Road, Hangzhou, 310006, Zhejiang, China.
J Cancer Res Clin Oncol. 2016 Mar;142(3):531-47. doi: 10.1007/s00432-015-1946-x. Epub 2015 Mar 4.
This review aims to summarize the evidence that Notch signaling is associated with prostate development, tumorigenesis and prostate tumor progression.
Studies in PubMed database were searched using the keywords of Notch signaling, prostate development and prostate cancer. Relevant literatures were identified and summarized.
The Notch pathway plays an important role in determining cell fate, proliferation, differentiation and apoptosis. Recent findings have highlighted the involvement of Notch signaling in prostate development and in the maintenance of adult prostate homeostasis. Aberrant Notch expression in tissues leads to dysregulation of Notch functions and promotes various neoplasms, including prostate cancer. High expression of Notch has been implicated in prostate cancer, and its expression increases with higher cancer grade. However, the precise role of Notch in prostate cancer has yet to be clearly defined. The roles of Notch either as an oncogene or tumor suppressor in prostate cancer hallmarks such as cell proliferation, apoptosis and anoikis, hypoxia, migration and invasion, angiogenesis as well as the correlation with metastasis are therefore discussed.
Notch signaling is a complicated signaling pathway in modulating prostate development and prostate cancer. Understanding and manipulating Notch signaling could therefore be of potential therapeutic value in combating prostate cancer.
本综述旨在总结Notch信号通路与前列腺发育、肿瘤发生及前列腺肿瘤进展相关的证据。
在PubMed数据库中使用Notch信号通路、前列腺发育和前列腺癌等关键词进行检索。识别并总结相关文献。
Notch通路在决定细胞命运、增殖、分化和凋亡中起重要作用。近期研究结果突出了Notch信号通路在前列腺发育及维持成年前列腺内环境稳定中的作用。组织中Notch表达异常导致Notch功能失调，并促进包括前列腺癌在内的各种肿瘤发生。Notch高表达与前列腺癌有关，且其表达随癌症分级升高而增加。然而，Notch在前列腺癌中的精确作用尚未明确界定。因此，本文讨论了Notch在前列腺癌特征（如细胞增殖、凋亡和失巢凋亡、缺氧、迁移和侵袭、血管生成）中作为癌基因或肿瘤抑制因子的作用，以及与转移的相关性。
Notch信号通路是调节前列腺发育和前列腺癌的复杂信号通路。因此，了解和调控Notch信号通路在对抗前列腺癌方面可能具有潜在的治疗价值。
