Liu Hong, Shao-Gang Ma, Liang Cheng, Feng Bai, Wei Xu
Faculty, Department of Endocrinology and Metabolism, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital , Huai'an, China .
J Clin Diagn Res. 2015 Jan;9(1):OC14-7. doi: 10.7860/JCDR/2015/11585.5475. Epub 2015 Jan 1.
To investigate whether serum levels of butyrylcho-linesterase activity, cystatin C, and pre-albumin has the potential value as γ-glutamyl transferase in reflecting gestational diabetes mellitus and its fetal outcome.
Seventy-six gestational diabetes mellitus women and 76 pregnancies with normal glucose tolerance in the second trimester were enrolled. Maternal serum parameters of butyrylcholinesterase activity, γ-glutamyl transferase, cystatin C, and pre-albumin were detected and evaluated. The pregnant complications and fetal outcome were also evaluated.
Levels of butyrylcholinesterase activity, γ-glutamyl transferase, cystatin C, pre-albumin and glycemic variables were higher in the gestational diabetes mellitus patients than in the controls. Levels of butyrylcholinesterase activity were significantly correlated to the levels of fasting plasma glucose, cystatin C, and γ- glutamyl transferase (p < 0.05) in the gestational diabetes mellitus group. There were statistical differences in cases of preterm delivery, preeclampsia and postpartum hemorrhage. Higher levels of γ-glutamyl transferase and pre-albumin were risk markers for gestational diabetes mellitus (p < 0.05). The diagnosis curve demonstrated that γ-glutamyl transferase had a significant advantage over other markers (p < 0.001) but no significance compared with pre-albumin (p = 0.096). None of the detected markers showed predictive value for fetal outcome.
Serum levels of butyrylcholinesterase activity, γ-glutamyl transferase, cystatin C and pre-albumin were correlated with gestational diabetes mellitus status but not with the fetal outcome. Pre-albumin can be equivalent as γ-glutamyl transferase in reflecting the presence of gestational diabetes mellitus.
探讨血清丁酰胆碱酯酶活性、胱抑素C和前白蛋白水平在反映妊娠期糖尿病及其胎儿结局方面是否具有与γ-谷氨酰转移酶相同的潜在价值。
纳入76例妊娠期糖尿病妇女和76例孕中期糖耐量正常的孕妇。检测并评估母体血清中丁酰胆碱酯酶活性、γ-谷氨酰转移酶、胱抑素C和前白蛋白的参数。同时评估妊娠并发症和胎儿结局。
妊娠期糖尿病患者的丁酰胆碱酯酶活性、γ-谷氨酰转移酶、胱抑素C、前白蛋白水平及血糖变量均高于对照组。妊娠期糖尿病组中，丁酰胆碱酯酶活性水平与空腹血糖、胱抑素C及γ-谷氨酰转移酶水平显著相关（p<0.05）。早产、子痫前期和产后出血病例存在统计学差异。γ-谷氨酰转移酶和前白蛋白水平较高是妊娠期糖尿病的风险标志物（p<0.05）。诊断曲线显示，γ-谷氨酰转移酶比其他标志物具有显著优势（p<0.001），但与前白蛋白相比无显著性差异（p=0.096）。所检测的标志物均未显示出对胎儿结局的预测价值。
血清丁酰胆碱酯酶活性、γ-谷氨酰转移酶、胱抑素C和前白蛋白水平与妊娠期糖尿病状态相关，但与胎儿结局无关。前白蛋白在反映妊娠期糖尿病的存在方面可与γ-谷氨酰转移酶等效。
