• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.BH3分析揭示疱疹病毒对特定Bcl-2蛋白的选择性，以介导潜伏感染细胞的存活。
J Virol. 2015 May;89(10):5739-46. doi: 10.1128/JVI.00236-15. Epub 2015 Mar 4.
2
Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection.抗凋亡细胞和病毒Bcl-2蛋白的选择性肽抑制剂在潜伏性卡波西肉瘤相关疱疹病毒感染期间导致细胞色素c释放。
Virus Res. 2016 Jan 4;211:86-8. doi: 10.1016/j.virusres.2015.10.007. Epub 2015 Oct 9.
3
[Herpesviruses survival strategies--latency and apoptosis].[疱疹病毒的生存策略——潜伏与凋亡]
Postepy Hig Med Dosw (Online). 2013 Apr 15;67:276-87. doi: 10.5604/17322693.1044688.
4
Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins.爱泼斯坦-巴尔病毒BALF1是一种与疱疹病毒抗凋亡BCL-2蛋白类似的BCL-2拮抗剂。
J Virol. 2002 Mar;76(5):2469-79. doi: 10.1128/jvi.76.5.2469-2479.2002.
5
Activation of human herpesvirus replication by apoptosis.细胞凋亡对人类疱疹病毒复制的激活作用
J Virol. 2013 Oct;87(19):10641-50. doi: 10.1128/JVI.01178-13. Epub 2013 Jul 24.
6
Notch and Wnt signaling: mimicry and manipulation by gamma herpesviruses.Notch和Wnt信号传导：γ疱疹病毒的模仿与操控
Sci STKE. 2006 May 16;2006(335):re4. doi: 10.1126/stke.3352006re4.
7
Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins.抗凋亡疱疹病毒Bcl-2同源物逃避半胱天冬酶介导的向促凋亡蛋白的转化。
J Virol. 2000 Jun;74(11):5024-31. doi: 10.1128/jvi.74.11.5024-5031.2000.
8
Herpesviral proteins regulating apoptosis.调节细胞凋亡的疱疹病毒蛋白
Curr Top Microbiol Immunol. 2002;269:257-72. doi: 10.1007/978-3-642-59421-2_15.
9
Analysis of viral cis elements conferring Kaposi's sarcoma-associated herpesvirus episome partitioning and maintenance.赋予卡波西肉瘤相关疱疹病毒附加体分配和维持功能的病毒顺式元件分析。
J Virol. 2007 Sep;81(18):9825-37. doi: 10.1128/JVI.00842-07. Epub 2007 Jul 11.
10
Herpesviruses hijack host exosomes for viral pathogenesis.疱疹病毒劫持宿主外泌体进行病毒发病机制。
Semin Cell Dev Biol. 2017 Jul;67:91-100. doi: 10.1016/j.semcdb.2017.03.005. Epub 2017 Apr 26.

引用本文的文献

1
Human Cytomegalovirus-Induced Autophagy Prevents Necroptosis of Infected Monocytes.人巨细胞病毒诱导的自噬可防止感染的单核细胞发生坏死性凋亡。
J Virol. 2020 Oct 27;94(22). doi: 10.1128/JVI.01022-20.
2
Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network.人巨细胞病毒通过 PI3K/SHIP1/Akt 信号网络介导独特的单核细胞向巨噬细胞分化。
Viruses. 2020 Jun 17;12(6):652. doi: 10.3390/v12060652.
3
Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma.疱疹病毒原发性渗出淋巴瘤中的基因必需性全景和可用药的致癌依赖性。
Nat Commun. 2018 Aug 15;9(1):3263. doi: 10.1038/s41467-018-05506-9.
4
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.爱泼斯坦-巴尔病毒通过在感染后的早期和晚期独特地调节细胞凋亡来确保B细胞存活。
Elife. 2017 Apr 20;6:e22509. doi: 10.7554/eLife.22509.
5
Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes.封装在纳米颗粒中的Mcl-1小分子抑制剂对人巨细胞病毒感染的单核细胞具有更高的杀伤效力。
Antiviral Res. 2017 Feb;138:40-46. doi: 10.1016/j.antiviral.2016.11.027. Epub 2016 Nov 30.
6
Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques.食蟹猴的跨物种恒河猴巨细胞病毒感染
PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi: 10.1371/journal.ppat.1006014. eCollection 2016 Nov.
7
Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.人巨细胞病毒诱导Akt的非典型激活以刺激短命单核细胞的存活。
J Virol. 2016 Jun 24;90(14):6443-6452. doi: 10.1128/JVI.00214-16. Print 2016 Jul 15.
8
Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes.人巨细胞病毒在病毒进入过程中刺激特定Akt依赖性抗凋亡蛋白的合成，以促进被感染单核细胞的存活。
J Virol. 2016 Jan 6;90(6):3138-47. doi: 10.1128/JVI.02879-15.
9
Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection.抗凋亡细胞和病毒Bcl-2蛋白的选择性肽抑制剂在潜伏性卡波西肉瘤相关疱疹病毒感染期间导致细胞色素c释放。
Virus Res. 2016 Jan 4;211:86-8. doi: 10.1016/j.virusres.2015.10.007. Epub 2015 Oct 9.
10
Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.在抗凋亡Bcl-2蛋白特异性格局中定位疱疹病毒Bcl-2同源物
J Mol Biol. 2015 Jul 31;427(15):2468-2490. doi: 10.1016/j.jmb.2015.05.015. Epub 2015 May 23.

本文引用的文献

1
CMV prophylaxis in hematopoietic-cell transplantation.造血细胞移植中的巨细胞病毒预防
N Engl J Med. 2014 Aug 7;371(6):576. doi: 10.1056/NEJMc1406756.
2
Mitochondrial priming of chronic lymphocytic leukemia patients associates Bcl-xL dependence with alvocidib response.慢性淋巴细胞白血病患者的线粒体启动将Bcl-xL依赖性与阿沃西迪布反应联系起来。
Leukemia. 2014 Nov;28(11):2251-4. doi: 10.1038/leu.2014.206. Epub 2014 Jul 3.
3
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.3-取代-N-(4-羟基萘-1-基)芳基磺酰胺作为新型选择性Mcl-1抑制剂：基于结构的设计、合成、构效关系及生物学评价
J Med Chem. 2014 May 22;57(10):4111-33. doi: 10.1021/jm500010b. Epub 2014 May 7.
4
Human herpesvirus-8: Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma.人类疱疹病毒8型：卡波西肉瘤、多中心性Castleman病和原发性渗出性淋巴瘤。
Hematology Am Soc Hematol Educ Program. 2013;2013:103-8. doi: 10.1182/asheducation-2013.1.103.
5
Structural biology of the Bcl-2 family and its mimicry by viral proteins.Bcl-2 家族的结构生物学及其病毒蛋白模拟。
Cell Death Dis. 2013 Nov 7;4(11):e909. doi: 10.1038/cddis.2013.436.
6
BH3 profiling discriminates response to cytarabine-based treatment of acute myelogenous leukemia.BH3 谱分析可区分急性髓系白血病基于阿糖胞苷的治疗反应。
Mol Cancer Ther. 2013 Dec;12(12):2940-9. doi: 10.1158/1535-7163.MCT-13-0692. Epub 2013 Oct 3.
7
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.ABT-199，一种强效和选择性的 BCL-2 抑制剂，在发挥抗肿瘤活性的同时不影响血小板。
Nat Med. 2013 Feb;19(2):202-8. doi: 10.1038/nm.3048. Epub 2013 Jan 6.
8
Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation.卡波西肉瘤相关疱疹病毒癌蛋白 K13 通过 NF-κB 激活来防止 B 细胞受体诱导的生长停滞和凋亡。
J Virol. 2013 Feb;87(4):2242-52. doi: 10.1128/JVI.01393-12. Epub 2012 Dec 12.
9
Treatment of cytomegalovirus disease in solid organ transplant recipients: markers of inflammation as predictors of outcome.实体器官移植受者巨细胞病毒病的治疗：炎症标志物作为结局预测因子。
Transplantation. 2012 Nov 27;94(10):1060-5. doi: 10.1097/TP.0b013e31826c39de.
10
A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.一项竞争性环肽筛选鉴定出一种能克服MCL-1依赖性白血病细胞存活的选择性小分子。
Chem Biol. 2012 Sep 21;19(9):1175-86. doi: 10.1016/j.chembiol.2012.07.018.

BH3分析揭示疱疹病毒对特定Bcl-2蛋白的选择性，以介导潜伏感染细胞的存活。

BH3 Profiling Reveals Selectivity by Herpesviruses for Specific Bcl-2 Proteins To Mediate Survival of Latently Infected Cells.

作者信息

Cojohari Olesea, Burrer Christine M, Peppenelli Megan A, Abulwerdi Fardokht A, Nikolovska-Coleska Zaneta, Chan Gary C

机构信息

Department of Microbiology & Immunology, SUNY Upstate Medical University, Syracuse, New York, USA.

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

出版信息

J Virol. 2015 May;89(10):5739-46. doi: 10.1128/JVI.00236-15. Epub 2015 Mar 4.

DOI:10.1128/JVI.00236-15
PMID:25740993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4442507/
Abstract

Herpesviruses, including human cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus, establish latency by modulating or mimicking antiapoptotic Bcl-2 proteins to promote survival of carrier cells. BH3 profiling, which assesses the contribution of Bcl-2 proteins towards cellular survival, was able to globally determine the level of dependence on individual cellular and viral Bcl-2 proteins within latently infected cells. Moreover, BH3 profiling predicted the sensitivity of infected cells to small-molecule inhibitors of Bcl-2 proteins.

摘要

疱疹病毒，包括人类巨细胞病毒（HCMV）、爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒，通过调节或模拟抗凋亡Bcl-2蛋白来建立潜伏状态，以促进载体细胞的存活。BH3分析可评估Bcl-2蛋白对细胞存活的贡献，它能够全面确定潜伏感染细胞对个体细胞和病毒Bcl-2蛋白的依赖程度。此外，BH3分析还可预测感染细胞对Bcl-2蛋白小分子抑制剂的敏感性。