Kaplan Lawrence D
1University of California, San Francisco, San Francisco, CA.
Hematology Am Soc Hematol Educ Program. 2013;2013:103-8. doi: 10.1182/asheducation-2013.1.103.
Human herpesvirus 8 (HHV8) is a gamma herpesvirus associated with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma, lymphoproliferative diseases that are most commonly observed in immunocompromised individuals. The viral genome expresses genes responsible for inhibition of apoptosis, cell cycle entry, and angiogenesis. Viral homologs of human regulatory genes are expressed, providing stimuli for angiogenesis, B-cell proliferation, and immune evasion. Variations in expression of these factors give rise to the 3 known HHV8-associated malignancies. Identification of these pathogenetic mechanisms has led to exploration of targeted treatment approaches for all 3 of these disorders with success in Kaposi sarcoma and multicentric Castleman disease; primary effusion lymphoma remains a clinical challenge.
人类疱疹病毒8型（HHV8）是一种γ疱疹病毒，与卡波西肉瘤、多中心Castleman病和原发性渗出性淋巴瘤相关，这些淋巴增殖性疾病最常见于免疫功能低下的个体。病毒基因组表达负责抑制细胞凋亡、进入细胞周期和血管生成的基因。人类调节基因的病毒同源物被表达，为血管生成、B细胞增殖和免疫逃逸提供刺激。这些因子表达的变化导致了3种已知的与HHV8相关的恶性肿瘤。对这些致病机制的识别促使人们探索针对所有这3种疾病的靶向治疗方法，在卡波西肉瘤和多中心Castleman病中取得了成功；原发性渗出性淋巴瘤仍然是一个临床挑战。
