用于稳定且可逆的聚合物 - 肽缀合物的二硫酚马来酰亚胺聚合物与催产素的原位缀合
In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates.
作者信息
Collins Jennifer, Tanaka Joji, Wilson Paul, Kempe Kristian, Davis Thomas P, McIntosh Michelle P, Whittaker Michael R, Haddleton David M
机构信息
†Department of Chemistry, University of Warwick, CV4 7AL, Coventry, United Kingdom.
出版信息
Bioconjug Chem. 2015 Apr 15;26(4):633-8. doi: 10.1021/bc5006202. Epub 2015 Mar 10.
The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.
报道了肽-聚合物生物共轭物的原位一锅法合成。共轭反应高效发生，无需纯化作为治疗性催产素二硫键桥连剂的二硫酚马来酰亚胺功能化聚合物。聚合物的共轭反应被证明是可逆的，并且能显著提高催产素在溶液中的稳定性。
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