Nilsson G, Ahlstedt S
Department of Allergy and Immunology, Pharmacia Diagnostics AB, Uppsala, Sweden.
Int Arch Allergy Appl Immunol. 1989;90(3):256-60. doi: 10.1159/000235033.
We studied the neuroimmunomodulatory effect of capsaicin on the development of delayed-type hypersensitivity (DTH) reaction and antibody formation after reduction of neuropeptides in the peripheral sensoric nervous system. Rats were sensitized with picryl chloride on their shaved abdomen or by subcutaneous injections with picrylsulfonic acid (PSA). Manipulation of the content of neuropeptides in the sensory nerve system with capsaicin was performed 1 week before or after sensitization. An increase of the DTH reaction assessed as increased ear thickness after challenge was seen especially when the rats were given capsaicin after sensitization. The formation of specific antibodies was not affected, although the level of total IgG was decreased in PSA-sensitized rats treated with capsaicin after sensitization. The results demonstrated that the DTH reaction in rat was slightly but significantly affected by the abolishment of neuropeptides in sensoric nerve endings with capsaicin. Even if the direct effect of capsaicin on the immune system still has to be elucidated, these results indicate that neuropeptides in sensory nerves are involved in the pathogenesis of DTH.
我们研究了辣椒素在外周感觉神经系统中神经肽减少后对迟发型超敏反应（DTH）发展及抗体形成的神经免疫调节作用。大鼠在剃毛的腹部用苦味酸氯致敏，或通过皮下注射苦味酸磺酸（PSA）致敏。在致敏前或致敏后1周，用辣椒素对感觉神经系统中的神经肽含量进行调控。尤其是在致敏后给大鼠注射辣椒素时，可观察到作为激发后耳厚度增加所评估的DTH反应增强。虽然在致敏后用辣椒素处理的PSA致敏大鼠中总IgG水平降低，但特异性抗体的形成未受影响。结果表明，辣椒素消除感觉神经末梢中的神经肽对大鼠的DTH反应有轻微但显著的影响。即使辣椒素对免疫系统的直接作用仍有待阐明，但这些结果表明感觉神经中的神经肽参与了DTH的发病机制。
