Gravelle Simon, Joly Laurent, Detcheverry François, Ybert Christophe, Cottin-Bizonne Cécile, Bocquet Lydéric
Institut lumière matière, UMR5306 université Lyon 1-CNRS, université de Lyon, 3, boulevard du 11 novembre 1918, 69622 Villeurbanne, France.
Institut lumière matière, UMR5306 université Lyon 1-CNRS, université de Lyon, 3, boulevard du 11 novembre 1918, 69622 Villeurbanne, France - Laboratoire de Physique Statistique, UMR CNRS 8550, École Normale Supérieure, 24, rue Lhomond, 75231 Paris Cedex 05, France.
Med Sci (Paris). 2015 Feb;31(2):174-9. doi: 10.1051/medsci/20153102014. Epub 2015 Mar 4.
Aquaporins are transmembrane proteins, ubiquitous in the human body. Inserted into the cell membranes, they play an important role in filtration, absorption and secretion of fluids. However, the excellent compromise between selectivity and permeability of aquaporins remains elusive. In this review, we focus on the hourglass shape of aquaporins, and we investigate its influence on water permeability, using numerical calculations and a simple theoretical model. We show that there is an optimum opening angle that maximizes the hydrodynamic permeability, and whose value is close to the angles observed in aquaporins.
水通道蛋白是跨膜蛋白，在人体中普遍存在。它们嵌入细胞膜，在液体的过滤、吸收和分泌中发挥重要作用。然而，水通道蛋白在选择性和渗透性之间的出色平衡仍不清楚。在本综述中，我们聚焦于水通道蛋白的沙漏形状，并使用数值计算和一个简单的理论模型研究其对水渗透性的影响。我们表明，存在一个最佳开口角度，可使流体动力渗透性最大化，其值接近在水通道蛋白中观察到的角度。
