Dickson E L, Vogel R I, Luo X, Downs L S
Department of Obstetrics, Gynecology and Women's Health, and Masonic Cancer Center,University of Minnesota,Minneapolis, MN,USA.
Biostatistics and Bioinformatics Core, Masonic Cancer Center,University of Minnesota,Minneapolis, MN,USA.
Epidemiol Infect. 2015 Apr;143(5):1042-7. doi: 10.1017/S0950268814001538.
SUMMARY This study examined recent trends in type-specific HPV infection rates in women referred for HPV typing as part of cervical cancer screening in the United States. HPV analyses were performed from March 2004 to March 2011. Women were aged 21-65 years at testing. The 18 most prevalent HPV types were analysed. Type-specific HPV infection rates were estimated in 3-month blocks. Lowess smoothing was used to examine time trends in infection rates for each HPV type, both combined, and separated by age group (younger women 21-30 years, older women 31-64 years). A total of 220914 women were included in the final analysis. The number of HPV tests performed on the younger age group increased, with the number of HPV infections and multiple type HPV infections decreasing. When separated by HPV type-specific analysis, the majority of HPV infection rates decreased; however, HPV types 61 and 83 increased. When analysing the older age group, there was a marked increase of the number of HPV tests. Overall, the rates of any HPV infection, as well as multiple type infections, were lower compared to the younger age group. The change in type-specific HPV rates in the older age group was minimal, with many rates remaining the same. In this population of women, overall rates of HPV infection decreased, while the number of HPV tests increased. Younger women had a more marked decrease in HPV infection rates, while for older women type-specific HPV infection rates appear consistent.
摘要 本研究调查了在美国作为宫颈癌筛查一部分而接受HPV分型检测的女性中特定类型HPV感染率的近期趋势。HPV分析于2004年3月至2011年3月进行。检测时女性年龄在21 - 65岁之间。对18种最常见的HPV类型进行了分析。按3个月时间段估算特定类型HPV感染率。采用局部加权回归平滑法（Lowess平滑法）来研究每种HPV类型感染率的时间趋势，包括总体趋势以及按年龄组（21 - 30岁年轻女性、31 - 64岁年长女性）分开的趋势。最终分析纳入了总共220914名女性。在较年轻年龄组中进行的HPV检测数量增加，而HPV感染数量和多重HPV类型感染数量减少。当按特定HPV类型分析时，大多数HPV感染率下降；然而，HPV 61型和83型感染率上升。在分析较年长年龄组时，HPV检测数量显著增加。总体而言，与较年轻年龄组相比，任何HPV感染率以及多重类型感染率都较低。较年长年龄组中特定类型HPV感染率的变化极小，许多感染率保持不变。在这群女性中，HPV总体感染率下降，而HPV检测数量增加。年轻女性的HPV感染率下降更为明显，而年长女性的特定类型HPV感染率似乎保持稳定。
