Gardella Barbara, Dominoni Mattia, Sosso Cecilia, Arrigo Anna, Gritti Andrea, Cesari Stefania, Fiandrino Giacomo, Spinillo Arsenio
Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Microorganisms. 2021 Mar 31;9(4):729. doi: 10.3390/microorganisms9040729.
Time trends prevalence of human papillomavirus (HPV) genotypes including negative and untypable infections were analyzed during a 15-year period (2005-2019) among 5807 subjects with abnormal pap-smears and/or cervical intraepithelial neoplasia (CIN). The rates of HPV16 dropped by 13% every 3 years (Prevalence Ratio, PR = 0.87, 95% CI = 0.82-0.93) in the CIN1 biopsy, while HPV16 status was unchanged over time in the CIN2+ biopsy. In CIN1 lesions, there was a corresponding increase of HR-HPV types unrelated to nonavalent vaccine. The rates of HPV 18, 31, and 52, decreased by 35% (PR = 0.65, 95% CI = 0.54-0.79), 19% (PR = 0.81, 95% CI = 0.73-0.91), and 21% (PR = 0.79, 95% CI = 0.73-0.86) every 3-year interval in CIN2+, respectively. Overall, the prevalence of negative/untypable HPV specimens in the entire database increased from 9.6% (129/1349) in the period 2011-2013 to 17.6% (161/913) and 28.4% (224/790) in the 2014-2016 period and in the 2017-2019 period, respectively (PR = 1.69, 95% CI = 1.52-1.88). HPV 16 prevalence decreased significantly among subjects with low-grade cervical squamous lesions. A significant increase of both HPV types unrelated to nonavalent vaccination and negative/untypable HPV infections was reported. The prevalence of HPV types among subjects with abnormal pap smears in Northern Italy is changing. Many variables including demographic factors and possibly vaccination could be responsible for this modification.
在15年期间（2005 - 2019年），对5807名巴氏涂片异常和/或宫颈上皮内瘤变（CIN）患者的人乳头瘤病毒（HPV）基因型流行趋势进行了分析，包括阴性和无法分型的感染情况。在CIN1活检中，HPV16的感染率每3年下降13%（患病率比，PR = 0.87，95%置信区间 = 0.82 - 0.93），而在CIN2 +活检中，HPV16的感染状态随时间未发生变化。在CIN1病变中，与九价疫苗无关的高危型HPV类型相应增加。在CIN2 +中，HPV 18、31和52的感染率每3年分别下降35%（PR = 0.65，95%置信区间 = 0.54 - 0.79）、19%（PR = 0.81，95%置信区间 = 0.73 - 0.91）和21%（PR = 0.79，95%置信区间 = 0.73 - 0.86）。总体而言，整个数据库中HPV阴性/无法分型标本的患病率从2011 - 2013年期间的9.6%（129/1349）分别增至2014 - 2016年期间的17.6%（161/913）和2017 - 2019年期间的28.4%（224/790）（PR = 1.69，95%置信区间 = 1.52 - 1.88）。在低度宫颈鳞状病变患者中，HPV 16患病率显著下降。报告显示，与九价疫苗无关的HPV类型以及HPV阴性/无法分型感染均显著增加。意大利北部巴氏涂片异常患者中HPV类型的患病率正在发生变化。包括人口统计学因素以及可能的疫苗接种等许多变量可能是导致这种变化的原因。
