Cayir Atilla, Kosan Celalettin
Department of Pediatric Endocrinology, Regional Training and Research Hospital, Erzurum, Turkey.
Department of Pediatric Nephrology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
Eurasian J Med. 2015 Feb;47(1):62-5. doi: 10.5152/eajm.2014.57. Epub 2014 Dec 5.
Growth is impaired in a chronic renal failure. Anemia, acidosis, reduced intake of calories and protein, decreased synthesis of vitamin D and increased parathyroid hormone levels, hyperphosphatemia, renal osteodystrophy and changes in growth hormone-insulin-like growth factor and the gonadotropin-gonadal axis are implicated in this study. Growth is adversely affected by immunosuppressives and corticosteroids after kidney transplantation. Treating metabolic disorders using the recombinant human growth hormone is an effective option for patients with inadequate growth rates.
慢性肾衰竭会导致生长发育受损。本研究涉及贫血、酸中毒、热量和蛋白质摄入减少、维生素D合成减少、甲状旁腺激素水平升高、高磷血症、肾性骨营养不良以及生长激素 - 胰岛素样生长因子和促性腺激素 - 性腺轴的变化。肾移植后，免疫抑制剂和皮质类固醇会对生长产生不利影响。对于生长速度不足的患者，使用重组人生长激素治疗代谢紊乱是一种有效的选择。
