用红豆凝集素（一种对人CD4+淋巴细胞有丝分裂原作用的凝集素）刺激HIV感染患者的外周血淋巴细胞。
Stimulation of peripheral blood lymphocytes of HIV-infected patients by jacalin, a lectin mitogenic for human CD4+ lymphocytes.
作者信息
Pineau N, Brugier J C, Breux J P, Becq-Giraudon B, Descamps J M, Aucouturier P, Preud'homme J L
机构信息
Laboratory of Immunology and Immunopathology (CNRS URA, 1172), France.
出版信息
AIDS. 1989 Oct;3(10):659-63. doi: 10.1097/00002030-198910000-00008.
The proliferative response of peripheral blood mononuclear cells stimulated by jacalin was investigated in 157 samples from 104 HIV-infected patients at various clinical stages of disease. Jacalin proliferative response correlated with the absolute numbers and percentages of CD4+ lymphocytes and with the percentages of Leu 8 lymphocytes. It correlated negatively with the percentages of CD8+ and CD38+ lymphocytes. It was depressed during acute HIV infection and at advanced stages. The response in Centers for Disease Control groups II and III was heterogeneous and similar; in both, some patients showed a very low response. Further follow-up of the present patients should indicate whether jacalin responsiveness has a prognostic value.
在104例处于不同疾病临床阶段的HIV感染患者的157份样本中，研究了红豆凝集素刺激外周血单个核细胞的增殖反应。红豆凝集素增殖反应与CD4 +淋巴细胞的绝对数量和百分比以及Leu 8淋巴细胞的百分比相关。它与CD8 +和CD38 +淋巴细胞的百分比呈负相关。在急性HIV感染期间和晚期，该反应受到抑制。疾病控制中心II组和III组的反应是异质性的且相似；在这两组中，一些患者的反应非常低。对目前这些患者的进一步随访应能表明红豆凝集素反应性是否具有预后价值。
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