Hashim O H, Gendeh G S, Jaafar M I
Department of Biochemistry, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Biochem Int. 1992 Jun;27(1):139-43.
The effect of extracts of champedak (Artocarpus integer) seed lectin on the proliferation of normal human lymphocyte was investigated. The IgA1 binding lectin was demonstrated to stimulate the proliferation of human peripheral blood mononuclear cells. Action of the lectin on enriched T and B cell populations demonstrated T lymphocyte specificity. The lectin was not mitogenic to B lymphocytes. Optimal stimulation of proliferative response was achieved when cells were subjected to 5 days exposure to the crude lectin at 20 micrograms/ml.
研究了波罗蜜（面包树）种子凝集素提取物对正常人淋巴细胞增殖的影响。已证实这种结合IgA1的凝集素能刺激人外周血单个核细胞的增殖。该凝集素对富集的T细胞和B细胞群体的作用显示出T淋巴细胞特异性。该凝集素对B淋巴细胞无促有丝分裂作用。当细胞在20微克/毫升的粗凝集素中暴露5天时，可实现增殖反应的最佳刺激。
