Dong Yichen, Chen Guohua, Gao Mingming, Tian Xia
Department of General Surgery, Laiwu People's Hospital, Laiwu 271100, Shandong, China.
Shandong University, Jinan 250100, Shandong, China.
Gene. 2015 May 25;563(1):29-34. doi: 10.1016/j.gene.2015.03.003. Epub 2015 Mar 4.
The role of matrix metalloproteinase 14 (MMP14) has been identified to involve tumor progression and prognosis. The purpose of this study is to investigate the role of MMP14 in tumor progression and prognosis of gastric cancer. This study indicated that MMP14 mRNA and protein were overexpressed in gastric cancer tissue (P<0.001 and P=0.037, respectively) and significantly associated with clinical stage (P=0.005), lymph node metastasis (P=0.003), and distant metastasis (P=0.017). Moreover, we found that the overexpression of MMP14 was a significant predictor of poor prognosis for gastric cancer patients (P<0.001). Furthermore, we performed a meta-analysis which included 594 cases from 3 studies and showed that MMP14 overexpression was a significantly poor prognostic factor in Chinese patients with gastric cancer and HR (95% CI) was 2.17 (1.64-2.86). In conclusion, MMP14 plays an important role on gastric cancer progression and prognosis and acts as a convictive biomarker for prognostic prediction for Chinese patients with gastric cancer.
基质金属蛋白酶14（MMP14）的作用已被证实与肿瘤进展和预后相关。本研究旨在探讨MMP14在胃癌肿瘤进展和预后中的作用。本研究表明，MMP14 mRNA和蛋白在胃癌组织中均有过表达（分别为P<0.001和P=0.037），且与临床分期（P=0.005）、淋巴结转移（P=0.003）及远处转移（P=0.017）显著相关。此外，我们发现MMP14的过表达是胃癌患者预后不良的重要预测指标（P<0.001）。进一步地，我们进行了一项荟萃分析，纳入了来自3项研究的594例病例，结果显示MMP14过表达是中国胃癌患者显著的不良预后因素，风险比（95%可信区间）为2.17（1.64 - 2.86）。总之，MMP14在胃癌进展和预后中起重要作用，是中国胃癌患者预后预测的可靠生物标志物。
